Selective Spinosyn J Hydrogenation Catalyst for Lower-Cost Yield
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Solution Overview
Problem
Existing catalysts for selectively reducing spinosyn J/L mixtures are costly, inefficient, and prone to side reactions, with low selectivity and long reaction times, making them unsuitable for large-scale production.
Innovation Solution
A catalyst comprising Pd, Pt, Rh, or Ru, with specific weight ratios and supported on carriers like activated carbon or alumina, is used to selectively reduce the 5,6-position double bond in spinosyn J without affecting the 13,14-position bond, in a hydrogenation process optimized for reaction time and yield.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If 5% Rh/Al2O3 catalyst is used for selective hydrogenation, then selectivity is improved, but production cost increases significantly due to high noble metal consumption
Solution Approach 1:
The patent changes the parameters of the catalyst by using non-noble metals (Pd, Pt, Rh, Ru, Ir) instead of noble metal Rh, and optimizes their weight ratios (first active metal:second active metal:secondary active metal = (6-12):(6-13):(1-2)) to achieve both high selectivity and reduced cost. The specific surface area of the carrier is also optimized (50-2000 m2/g) to enhance catalytic efficiency.
Solution Approach 2:
The patent replaces expensive noble metal catalysts with more economical non-noble metal catalysts that can be used in heterogeneous form, reducing the overall production cost while maintaining acceptable performance through optimized composition and reaction conditions.
2Quantity of substance
If 5% Pd/C catalyst is used for hydrogenation, then production cost is reduced, but selectivity decreases and reaction time increases leading to side reactions
Solution Approach 1:
The patent employs composite catalysts containing multiple active metals (Pd, Pt, Rh, Ru, Ir) in specific ratios supported on carriers with optimized surface areas. This composite structure synergistically combines the advantages of different metals to achieve high selectivity while maintaining reasonable cost, overcoming the limitations of single-metal catalysts.
Solution Approach 2:
The patent optimizes multiple parameters including the weight ratios of active metals, the specific surface area of the carrier, and reaction conditions (temperature, pressure, solvent) to enhance selectivity and reduce reaction time, thereby preventing side reactions while keeping production costs manageable.
3Stability of the object's composition
If ethylation is performed before hydrogenation, then product stability is improved, but reaction time increases and side reactions occur
Solution Approach 1:
The patent performs ethylation as a preliminary step before hydrogenation to protect the spinosyn molecule and improve stability during the subsequent hydrogenation process. The optimized catalyst and reaction conditions ensure that this preliminary action does not significantly extend the overall production time.
Solution Approach 2:
The patent optimizes the ethylation and hydrogenation reaction parameters (temperature, pressure, catalyst loading, solvent type) to minimize reaction time while maintaining product stability and preventing side reactions throughout the multi-step process.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The catalyst achieves high conversion rates and selectivity for 5,6-dihydro-spinosyn J production, reducing production costs and minimizing side reactions, with yields exceeding 90% in various embodiments.
Implementation Method 1
a catalyst for selectively reducing spinosyn J... the catalyst comprises an active component and a carrier... the active component is selected from a group consisting of Pd, Pt, Rh, Ru and Ir
Implementation Method 2
selective hydrogenation reduction of a mixture of spinosyn J/L... selectively catalyze and reduce a 5,6-position double bond on a spinosyn J four-membered ring lactone
Data Source
AI summary
The present application relates to the technical field of spinosyn preparation, in particular to a catalyst for selectively reducing spinosyn J. The weight of the active component in the catalyst accounts for 1%-10% of the weight of the catalyst, and the active component is one selected from Pd, Pt, Rh, Ru and Ir; the active component comprises at least two metals, a first metal is selected from the group consisting of Pd, Pt or Rh, and the remaining metal is any one or more than one selected from the group consisting of Pd, Pt, Ru and Ir. The catalyst can reduce a 5,6-position double bond on a spinosyn J four-membered ring lactone in a spinosyn J/L mixture by reacting with hydrogen under the conditions of 0.05 MPa-0.5 MPa and 10° C.-80° C. for 5 h-10 h, without accompanying reduction of a 13,14-position double bond on the spinosyn J four-membered ring lactone and spinosyn L. The catalyst conversion rate, selectivity and yield of the present application are higher, and the cost is lower.