Spiral Flow Effectuator for Adipose Tissue Fragmentation

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Solution Overview

Problem

Existing methods for adipose tissue harvesting and processing often cause trauma to adipose-derived stem cells (ADSCs), leading to reduced viability and effectiveness in biomedical and cosmetic applications.

Innovation Solution

A device comprising an upper housing, a lower housing, a filter stack, and a spiral flow effectuator, designed to minimize direct shock of adipose tissue with walls, promoting enhanced mechanical separation with less trauma to cells.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If conventional mechanical separation methods are used to separate ADSCs from adipose tissue, then separation efficiency is improved, but cell trauma increases leading to reduced viability

Engineering Contradiction:

Improveseparation efficiencyVSAvoidcell viability

Core Design Contradiction:

ProductivityVSReliability

Solution Approach 1:

The device segments the mechanical separation process into multiple stages with progressively smaller filter孔径 (pore sizes). The filter stack includes multiple filters with different pore sizes (e.g., 380 μm, 250 μm, 150 μm) that progressively separate adipose tissue into finer fragments, enabling efficient separation while controlling mechanical stress on cells at each stage

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The spiral flow effectuator creates a cushioning effect by generating spiral motion that reduces direct impact forces between adipose tissue and filter walls. This preliminary cushioning of mechanical stress before separation occurs protects cells from trauma while maintaining separation efficiency

Inventive Principle:

Principle #11Beforehand cushioning (Prior cushioning)

2Speed

If direct mechanical impact is applied to adipose tissue for separation, then separation speed is improved, but cell trauma increases

Engineering Contradiction:

Improveseparation speedVSAvoidmechanical trauma

Core Design Contradiction:

SpeedVSObject-affected harmful factors

Solution Approach 1:

The spiral flow effectuator uses curved spiral geometry to guide adipose tissue through a rotational path rather than direct linear impact. This curvature transforms direct mechanical shock into gradual spiral motion, maintaining separation speed while significantly reducing cell trauma from direct wall impacts

Inventive Principle:

Principle #14Spheroidality (Curvature)

Solution Approach 2:

The device converts the potentially harmful direct impact force into beneficial spiral flow motion. The mechanical energy that would cause trauma is redirected into controlled spiral movement through the filter stack, transforming a harmful effect into a gentle separation mechanism

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The device effectively enhances the mechanical separation of ADSCs from adipose tissue with reduced trauma, leading to improved viability and yield of stromal vascular fraction (SVF) for use in medical and cosmetic procedures.

Implementation Method 1

the spiral effectuate is configured to receive a flow of filtrate from the filter stack and generate a spiral flow of the adipose tissue to minimize a direct shock of the adipose tissue with walls of the filter stacker

Methodology Applied

Scientific EffectSpiral flow: Vortex Ring

Implementation Method 2

a filter stack, wherein the upper housing and the lower housing are configured to join to form an enclosure that encloses the filter stack and the spiral flow effectuator

Methodology Applied

Scientific EffectPhysical filtration: Filter (physical)

Data Source

PatentUS20250043233A1Fat fragmentation device and method

Publication Date: 2025.02.06 THE DUKE LTD

AI summary

The present disclosure provides a device for adipose tissue processing, microfragmentation and facilitation of mechanical separation of adipose derived stem cells (“ADSCs”), methods of fabricating the device, by, e.g., 3D printing.