Spiro Compound Receptor Antagonism for Butyric Acid Malodors
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Solution Overview
Problem
Existing malodor counteracting (MOC) compositions and ingredients are inadequate in effectively reducing, preventing, or inhibiting the perception of malodors, particularly those containing butyric acid, in environments such as latrines, laundry, and sweat, as they do not sufficiently target specific olfactory receptors.
Innovation Solution
The use of spiro compounds, including (2,3,9,9-tetramethylspiro[4.5]dec-2-en-10-yl) acetate and 1,5,10,10-tetramethylspiro[5.5]undec-3-en-11-yl acetate, which act as antagonists to specific olfactory receptors, particularly the butyric acid olfactory receptor, to reduce or inhibit the perception of malodors.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If existing malodor counteracting compositions are used, then general malodor suppression is achieved, but specific targeting of olfactory receptors (particularly butyric acid receptors) is insufficient
Solution Approach 1:
The patent applies local quality by designing spiro compounds with specific molecular structures (including spiro[4.5]decane and spiro[5.5]undecane skeletons) that are tailored to interact with specific olfactory receptors, particularly butyric acid receptors. This targeted molecular design enables selective binding to specific receptor subtypes rather than general receptor activation, thereby improving both specificity and effectiveness simultaneously.
Solution Approach 2:
The patent utilizes parameter changes by systematically varying molecular parameters such as the spiro ring size (4.5 vs 5.5), substituent positions (2,3,9,9-tetramethyl vs 1,5,10,10-tetramethyl), and functional group modifications to optimize compound affinity for specific olfactory receptors. These parameter variations create a series of compounds with differentiated specificities, allowing selection based on target receptor type.
2Reliability
If spiro compounds with specific structures are used, then binding affinity to olfactory receptors is improved, but synthesis complexity increases
Solution Approach 1:
The patent applies segmentation by dividing the spiro compound synthesis into modular steps: first constructing the spiro cyclic skeleton (e.g., spiro[4.5]decane or spiro[5.5]undecane core), then introducing methyl substituents at specific positions, and finally adding functional groups (acetate, formate, or hydroxyl). This stepwise modular approach simplifies the overall synthesis process compared to building complex molecules in a single operation, while maintaining the precise structural requirements for high binding affinity.
3Adaptability or versatility
If a broad spectrum malodor counteracting agent is used, then coverage of multiple malodor types is achieved, but effectiveness against specific butyric acid malodors is reduced
Solution Approach 1:
The patent segments the malodor counteracting strategy into receptor-specific compounds. Instead of using a single broad-spectrum agent, the invention provides distinct spiro compounds tailored for specific receptor families: compounds with spiro[4.5]decane skeletons for certain receptor subtypes and compounds with spiro[5.5]undecane skeletons for other subtypes, including specific butyric acid receptors. This segmentation allows each compound to be optimized for its target receptor, ensuring high effectiveness against butyric acid malodors while maintaining the option to select appropriate compounds for other malodor types.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
These spiro compounds effectively inhibit the perception of malodors by targeting specific olfactory receptors, providing a more targeted and effective solution for reducing malodors in environments like latrines, laundry, and sweat.
Implementation Method 1
spiro compounds, including (2,3,9,9-tetramethylspiro[4.5]dec-2-en-10-yl) acetate and 1,5,10,10-tetramethylspiro[5.5]undec-3-en-11-yl acetate, which act as antagonists to specific olfactory receptors
Data Source
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AI summary
The various aspects presented herein relate to the perfumery industry. More particularly, the various aspects presented herein relate to malodor counteracting compositions and/or ingredients, methods for counteracting malodors, as well as to the perfumed articles or perfuming compositions comprising as an active ingredient, at least one compound selected from the group consisting of: a compound of Formula (I), a compound of Formula (II), a compound of Formula (III), a compound of Formula (IV), and mixtures thereof.