Splenic Nerve Stimulation for Acute Shock Blood Pressure Stabilization
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Solution Overview
Problem
There is a need for improved treatments for acute medical conditions such as trauma, hemorrhaging, and septic shock, as existing treatments are often unsuccessful and life-threatening if left untreated.
Innovation Solution
Electrical stimulation of the splenic arterial nerves to modulate neural activity, which stabilizes blood pressure and improves physiological parameters in conditions like trauma, hemorrhaging, and septic shock.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing treatments are used for acute medical conditions, then treatment options are limited, but survival rates remain low and treatments are often unsuccessful
Solution Approach 1:
The patent applies electrical stimulation with specific parameters (frequency, amplitude, pulse duration) to the splenic nerve to modulate its activity. By changing the electrical parameters of stimulation, the treatment can be optimized for different acute conditions (septic shock, hemorrhage, trauma) to improve survival rates and treatment success where existing therapies have failed
Solution Approach 2:
The electrical stimulation of the splenic nerve serves multiple functions across different acute medical conditions. A single intervention approach (neuromodulation) addresses diverse conditions including septic shock, hemorrhagic shock, and trauma, providing versatile treatment options where condition-specific treatments have limited success
2Stability of the object's composition
If electrical stimulation of splenic nerves is applied, then blood pressure is stabilized and physiological parameters improve, but the mechanism of action in acute conditions was previously uninvestigated
Solution Approach 1:
The electrical stimulation parameters can be adjusted based on monitored physiological parameters (blood pressure, heart rate, oxygen saturation). The stimulation provides feedback-driven stabilization of blood pressure by modulating splenic nerve activity in response to the subject's physiological state, making the pro-survival effects more reliable and controllable in acute conditions
Data Source
AI summary
Electrical stimulation of neural activity in the neural innervation of the spleen that is associated with neurovascular bundles provides a useful way to treat acute medical conditions, such as trauma, hemorrhaging and shock.