Split-Flow ELS Detection for Sample Recovery and Low Sample Loss
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Solution Overview
Problem
Existing evaporation light scattering (ELS) detection devices require complete sample introduction, leading to sample destruction and lack of sample recovery, and do not allow simultaneous sample introduction and atomization.
Innovation Solution
A device with a conduit, atomizer, and detector unit, featuring a valve that switches between single-flow and split-flow configurations, allowing a portion of the sample to bypass the atomizer for recovery and another portion to be introduced into the atomizer for detection, minimizing sample loss.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If complete sample introduction is used for ELS detection, then detection sensitivity is improved, but sample loss increases and sample recovery becomes impossible
Solution Approach 1:
The sample flow is divided into two separate paths using a flow splitter: one path directs a portion of the sample to the ELS detector for sensitive detection, while the other path allows the remaining sample to be collected or further analyzed. This segmentation resolves the contradiction by enabling both high detection sensitivity and sample recovery simultaneously.
Solution Approach 2:
Instead of destroying the entire sample in the ELS detector, the system recovers the majority of the sample through the second path while only sacrificing a minimal portion for detection. This principle directly addresses the contradiction by maximizing sample recovery while maintaining detection capability.
2Productivity
If sample introduction and atomization occur simultaneously in the same device, then detection efficiency is improved, but sample loss increases due to complete destruction
Solution Approach 1:
The system segments the sample flow into detection and recovery paths, allowing simultaneous introduction and atomization for the detection portion while preserving the rest of the sample for recovery or further use.
Solution Approach 2:
Only a partial amount of the sample is subjected to atomization and destruction in the ELS detector, while the excess sample is diverted to the recovery path. This partial action resolves the contradiction by maintaining detection efficiency with minimal sample loss.
3Adaptability or versatility
If a valve is added to enable split-flow configuration, then sample recovery capability is improved, but device complexity increases
Solution Approach 1:
A flow splitter acts as an intermediary device that简单地 divides the sample flow into two paths based on pressure differential, enabling sample recovery capability without requiring complex multi-position valves or sophisticated control mechanisms. This intermediary approach resolves the contradiction by adding minimal complexity.
Solution Approach 2:
The flow splitter operates automatically based on pressure differential between the two paths, eliminating the need for complex external control systems. The system self-regulates the sample distribution, improving versatility while keeping device complexity low.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables simultaneous sample introduction and atomization with minimal sample quantity, allowing for additional detection and recovery, reducing sample loss and optimizing detection efficiency.
Implementation Method 1
A nebulizer is connected to a nebulization unit. A purge gas and a nebulization gas are introduced through the nebulization unit. A nebulization chamber is coupled to the nebulization unit, where the sample is nebulized at the end of a tip with the nebulization gas.
Implementation Method 2
evaporation tube, where the sample is nebulized at the end of a tip with the nebulization gas. The nebulized sample is then transferred to the nebulization chamber.
Data Source
Figure 1A
Figure 1B
Figure 2~3
AI summary
The invention relates to a device (1a, 1b) for detecting evaporative light scattering of a sample. The device comprises: a line (25) for conducting a medium containing a sample in a main flow direction of the device (1a, 1b); an atomiser which can be connected to the line (25) for conveying a liquid; an evaporation tube (5); and a detector unit (6). The evaporation tube (5) forms a fluid connection between the atomiser (23) and the detector unit (6). A valve (21) is arranged between the line (25) and the atomiser and can be switched between a single-flow configuration and a split-flow configuration. In the split-flow configuration, a first measurement portion of a medium containing a sample can be input into the atomiser from the line.