SPM-Enriched Oils via Fractionation for Inflammation Resolution
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Solution Overview
Problem
Current methods lack effective nutritional and pharmaceutical formulations containing Specialized Proresolving Mediators (SPMs) and their precursors to inhibit or resolve inflammation, relying on costly chemical synthesis or insufficient natural sources.
Innovation Solution
Development of oils enriched with SPMs and SPM precursors from natural sources, such as fish, krill, and algae, using fractionation techniques like supercritical fluid extraction and chromatography to produce anti-inflammatory and resolution-stimulating compositions for nutritional and pharmaceutical use.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If chemical synthesis is used to produce SPMs, then purity and concentration can be controlled, but production cost increases significantly
Solution Approach 1:
The patent extracts SPMs and their precursors directly from natural sources (fish oil, krill oil, algae oil) through fractionation techniques, eliminating the need for costly chemical synthesis while obtaining the desired compounds in their natural form
Solution Approach 2:
The patent uses fractionation techniques to separate and concentrate SPMs from crude oil extracts, changing the concentration parameter of SPMs in the final product without requiring chemical synthesis, thereby reducing production costs while maintaining controlled purity
2Ease of manufacture
If natural sources are used for SPMs, then production cost decreases, but SPM concentration and availability are insufficient
Solution Approach 1:
The patent applies fractionation techniques to naturally derived oils to concentrate and purify SPMs, changing the concentration parameter from trace amounts in crude oil to therapeutic levels in the final product, thereby increasing SPM availability while maintaining cost-effectiveness
Solution Approach 2:
The patent creates composite oil formulations containing multiple components including SPMs, SPM precursors, and other beneficial lipid components from natural sources, providing a synergistic composition that delivers sufficient SPM concentration along with additional health benefits
3Quantity of substance
If fractionation techniques are applied to natural oils, then SPM concentration increases, but processing complexity increases
Solution Approach 1:
The patent divides the crude oil extract into multiple fractions through sequential fractionation, separating SPMs from other components based on their different physical and chemical properties, thereby concentrating SPMs while using a systematic multi-step process that manages complexity through organized separation
4Ease of manufacture
If SPMs are extracted from crude oil, then natural sourcing is achieved, but purity and concentration are low
Solution Approach 1:
The patent systematically extracts SPMs from crude natural oil sources through multiple fractionation steps, progressively separating and concentrating the desired compounds while removing impurities, thereby achieving high purity while maintaining the natural origin of the SPMs
Solution Approach 2:
The patent changes the purity parameter of SPMs through fractionation, transforming crude extracts containing trace amounts of SPMs into highly purified and concentrated products suitable for therapeutic use, while preserving the natural characteristics of the originally sourced compounds
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
These oils effectively reduce inflammation and stimulate resolution, providing a natural, cost-effective alternative to chemical synthesis, with measurable anti-inflammatory and proresolving activities demonstrated in murine models.
Implementation Method 1
using fractionation techniques like supercritical fluid extraction and chromatography to produce anti-inflammatory and resolution-stimulating compositions
Implementation Method 2
using fractionation techniques like supercritical fluid extraction and chromatography to produce anti-inflammatory and resolution-stimulating compositions
Data Source
AI summary
The present invention encompasses oils that have anti-inflammatory or resolution-stimulating activity that contain or are enriched with Specialized Proresolving Mediators (SPM) or SPM precursors, which originate from an oil obtained from organisms containing long chain omega-3 polyunsaturated fatty acids, such as fish, crustaceae, algae, and mollusks. The invention also encompasses a method for the production of these oils, and the utilization of the oils for nutritional supplements, pharmaceutical formulations, and cosmetic formulations, which can be employed for treating an inflammatory condition.