Spore-Based Probiotics for Sebum Reduction and Skin Hydration

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Solution Overview

Problem

Current probiotic compositions do not effectively modulate dermal and sub-dermal properties, particularly in reducing sebum production and improving skin hydration, while existing treatments for skin conditions like acne often lead to antibiotic resistance and gut dysfunction.

Innovation Solution

A spore-based probiotic composition comprising strains Bacillus indicus (HU36), Bacillus subtilis (HU58), Bacillus coagulans SC-208, Bacillus clausii SC-109, and Bacillus licheniformis is administered to modulate dermal and sub-dermal properties, reducing sebum excretion and increasing skin hydration.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional probiotic compositions are used, then general gut health is improved, but dermal and sub-dermal properties such as sebum production and skin hydration are not effectively modulated

Engineering Contradiction:

Improveeffectiveness in modulating dermal propertiesVSAvoidsebum excretion reduction and skin hydration improvement

Core Design Contradiction:

ReliabilityVSProductivity

Solution Approach 1:

The patent changes the key parameter from generic probiotic strains to specific spore-based Bacillus strains (B. indicus, B. subtilis, B. coagulans, B. clausii, B. licheniformis) with proven dermal benefits. This strain selection parameter change enables effective modulation of sebum production and skin hydration that conventional probiotics cannot achieve.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent introduces spore-based probiotics as an intermediary mechanism that connects gut health improvement with dermal property modulation. The spores survive gastric acid, colonize the gut, and through the gut-skin axis, mediate changes in sebum production and skin hydration, bridging the gap between gut and skin health.

Inventive Principle:

Principle #24Intermediary (Mediator)

2Object-affected harmful factors

If antibiotics are used to treat skin conditions like acne, then skin symptoms are reduced, but antibiotic resistance and gut dysfunction occur

Engineering Contradiction:

Improveskin condition symptomsVSAvoidantibiotic resistance and gut dysfunction

Core Design Contradiction:

Object-affected harmful factorsVSObject-generated harmful factors

Solution Approach 1:

The patent converts the harmful effect of conventional antibiotic use into a beneficial alternative by using probiotic spores that naturally modulate sebum production and treat acne without causing resistance or gut dysfunction. The spores' ability to survive gastric acid and colonize the gut becomes a beneficial feature rather than a limitation.

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Solution Approach 2:

The spore-based probiotics self-regulate sebum production and skin hydration through their metabolic activity in the gut, which then influences skin health via the gut-skin axis. This self-service mechanism eliminates the need for external antibiotics and their associated harmful side effects.

Inventive Principle:

Principle #25Self-service

3Productivity

If spore-based probiotics are administered, then sebum excretion is reduced and skin hydration is increased, but the mechanism of action through the gut-skin axis requires further understanding

Engineering Contradiction:

Improvesebum excretion reduction and skin hydration improvementVSAvoidmechanism understanding

Core Design Contradiction:

ProductivityVSLoss of information

Solution Approach 1:

The patent establishes a feedback loop where spore-based probiotics modify gut microbiota composition, which in turn influences skin health outcomes. The measurable changes in sebum production and skin hydration provide feedback that validates the gut-skin axis mechanism, allowing for optimization of strain selection and dosing.

Inventive Principle:

Principle #23Feedback

Data Source

PatentUS11786563B2Spore-based probiotic composition for modulation of dermal and sub-dermal properties

Publication Date: 2023.10.17 NOVOZYMES AS

AI summary

The present invention relates to methods of modulating dermal and sub-dermal properties of a subject. The present invention relates to methods comprising administering to a subject a spore-based probiotic composition.