Sporoderm-Removed Ganoderma Lucidum Spore Tablet Formulation
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Solution Overview
Problem
Ganoderma lucidum spores have a hard sporoderm composed of chitin and cellulose, making them difficult to absorb in the body, and existing methods of breaking the sporoderm result in low mass fractions of active constituents in spore powders.
Innovation Solution
A tablet formulation of sporoderm-removed Ganoderma lucidum spore powder, comprising 13-20 parts of sporoderm-disrupted Ganoderma lucidum spore powder, 3-5 parts of sorbitol, and 0.8-1.2 parts of povidone K30, with a higher content of polysaccharides and triterpenes, prepared through water extraction, concentration, drying, and pulverization, to enhance bioavailability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If the sporoderm is crushed by grinding or milling method, then the absorption of Ganoderma lucidum spore is improved, but the mass fractions of active constituents are still very low
Solution Approach 1:
The patent removes the sporoderm (hard outer shell) from Ganoderma lucidum spores through enzymatic treatment, extracting only the necessary active constituents while discarding the indigestible outer layer. This resolves the contradiction by taking out the problematic sporoderm that prevented absorption while preserving the valuable active ingredients inside.
Solution Approach 2:
The patent changes the physical and chemical parameters of the spore structure by using enzymatic hydrolysis to break down the sporoderm's chitin and cellulose walls. This parameter change transforms the hard, indigestible sporoderm into soluble components, enabling absorption while releasing the active constituents with high mass fractions.
2Ease of manufacture
If the sporoderm is broken by grinding or milling, then the spore powder can be obtained, but the fragments of sporoderm remain in the spore powder
Solution Approach 1:
The patent extracts and removes the sporoderm fragments from the spore powder through enzymatic degradation. The enzymes specifically target and break down the chitin and cellulose in the sporoderm, separating these fragments from the active constituents and allowing their removal, thus achieving high purity spore powder without manual grinding fragments.
Solution Approach 2:
The patent replaces the mechanical grinding and milling system with a biochemical system using enzymes to break down the sporoderm. This substitution eliminates the need for mechanical force that creates fragments, instead using selective enzymatic hydrolysis to dissolve the sporoderm walls and release intact active constituents.
3Quantity of substance
If water extraction, concentration, drying and pulverization are used, then the aqueous extract is obtained with higher active constituents, but the processing time is increased
Solution Approach 1:
The patent performs preliminary enzymatic treatment to break down the sporoderm walls before water extraction. This preliminary action pre-digests the chitin and cellulose structure, making the active constituents more accessible and significantly reducing the time required for subsequent extraction, concentration, and drying processes while maintaining high yields of polysaccharides and triterpenes.
Solution Approach 2:
The patent changes the physical state and accessibility of active constituents through enzymatic hydrolysis, transforming them from being trapped in intact sporoderm to being readily extractable. This parameter change in molecular accessibility accelerates the extraction rate and reduces processing time while increasing the concentration of active constituents in the final product.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The tablet formulation significantly increases the absorption of active components, effectively enhancing immunity and providing anti-radiation and anti-tumor effects, with improved bioavailability and convenience of use.
Implementation Method 1
which is prepared by water extraction, concentration, drying and pulverization of the sporoderm-disrupted Ganoderma lucidum spore powder
Implementation Method 2
water extraction, concentration, drying and pulverization
Implementation Method 3
water extraction, concentration, drying and pulverization
Data Source
AI summary
The present invention provides a tablet of sporoderm-removed Ganoderma lucidum spore, which includes the following raw materials by weight parts: 13-20 parts of an aqueous extract of sporoderm-disrupted Ganoderma lucidum spore powder, 3-5 parts of sorbitol, and 0.8-1.2 parts of povidone K30; A method for preparing the tablet of sporoderm-removed Ganoderma lucidum spore includes the following steps: mixing the aqueous extract of sporoderm-disrupted Ganoderma lucidum spore powder, sorbitol and povidone K30 for 10-30 min, and subjecting the obtained mixture to granulating, screening and drying to obtain a granular material; and tableting the granular material to obtain the tablet of sporoderm-removed Ganoderma lucidum spore. The tablet of sporoderm-removed Ganoderma lucidum spore has a much higher content of active components, which are also easier to be absorbed. The tablet of sporoderm-removed Ganoderma lucidum spore is of effectively enhancing the body immunity and have anti-radiation and anti-tumor effects; and the dosage form of the tablet is convenient to carry and take.