Spray-Dried Metal-Organic Frameworks for Pulmonary Disease Treatment
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current treatments for tuberculosis (TB) are lengthy, cause systemic side effects, and are ineffective against multi-drug resistant (MDR) and extensively drug resistant (XDR) TB strains, with a need for more effective therapeutic and diagnostic approaches for pulmonary diseases.
Innovation Solution
Development of spray-dried metal-organic frameworks (MOFs) comprising specific metal ions and organic ligands, which can be administered via inhalation, targeting the lungs to treat and diagnose TB and other pulmonary diseases, with properties for biomedical imaging.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If oral and subcutaneous TB regimens are used, then therapeutic effect is achieved, but treatment duration is long (≥6 months) and systemic side effects occur
Solution Approach 1:
The patent uses inhalation as an intermediary delivery route to administer TB therapy directly to the lungs, bypassing the gastrointestinal tract and systemic circulation. This localized delivery method achieves therapeutic effect at the infection site while avoiding systemic side effects and reducing treatment duration
Solution Approach 2:
The invention employs local administration of therapeutic agents directly to the pulmonary site of infection through inhalation. This localized approach concentrates the therapeutic effect where needed (in the lungs) while minimizing exposure and side effects in other body systems, thereby reducing overall treatment duration
2Reliability
If oral and subcutaneous TB regimens are used, then therapeutic effect is achieved, but systemic side effects occur increasing transmission risks and compliance issues
Solution Approach 1:
Inhalation serves as an intermediary delivery route that directly transports therapeutic agents to the pulmonary infection site, bypassing systemic circulation. This eliminates or reduces systemic side effects while maintaining therapeutic efficacy, thereby improving patient compliance and reducing transmission risks
Solution Approach 2:
The invention delivers therapy locally to the lungs through inhalation, concentrating the therapeutic effect at the site of infection. This localized approach minimizes exposure of other body systems to therapeutic agents, reducing systemic side effects and their associated harmful consequences
3Reliability
If current TB regimens are used, then some therapeutic effect is achieved, but they are ineffective against multi-drug resistant (MDR) and extensively drug resistant (XDR) TB strains
Solution Approach 1:
The inhalation delivery platform provides a universal route of administration that can deliver multiple different therapeutic agents directly to the pulmonary site. This multi-functional approach allows the same delivery system to be used for both drug-sensitive and drug-resistant TB strains by simply changing the therapeutic agent, thereby achieving versatility against different resistance patterns
Solution Approach 2:
The invention enables parameter changes in the therapeutic approach by delivering different drugs through the same inhalation route. This allows adaptation to resistant strains by changing the chemical parameters of the therapeutic agent while maintaining the effective local delivery mechanism, thus achieving versatility against MDR and XDR strains
4Adaptability or versatility
If spray-dried MOFs are administered via inhalation, then targeted treatment and diagnostic imaging are achieved, but device complexity increases
Solution Approach 1:
The patent merges therapeutic and diagnostic functions into a single inhalable MOF formulation. The metal ions provide both therapeutic activity against TB and imaging capabilities for diagnosis and monitoring. This combination eliminates the need for separate administration of therapeutic and diagnostic agents, simplifying the overall treatment protocol despite the sophisticated nature of the MOF formulation
Solution Approach 2:
The MOF formulation serves multiple functions simultaneously: it acts as a therapeutic agent against TB, a diagnostic imaging contrast agent, and a targeted delivery vehicle. This multi-functionality achieves both targeted treatment and diagnostic capability through a single formulation, making the system versatile despite the inherent complexity of MOF chemistry
Data Source
AI summary
Spray-dried metal-organic frameworks (MOFs) comprising therapeutic and/or diagnostic metal ions and therapeutic and/or diagnostic organic ligands are described. Both the metal ion and organic ligand can have activity related to the treatment and/or diagnosis of a pulmonary disease or disorder, such as tuberculosis, or another disease related to a pulmonary infection. The MOFs can be adminstered to subjects via inhalation (e.g., as aerosols). Methods of treating and diagnosing pulmonary diseases or disorders are also described.