Sprayable Vitamin D3 Oily Formulation for Pediatric Administration
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current formulations of liposoluble vitamins, particularly vitamin D, lack a sprayable liquid form, which is essential for effective administration due to their liposoluble nature, and existing oily solutions are cumbersome and have poor bioavailability when used in pediatric and adolescent populations.
Innovation Solution
A sprayable oily liquid formulation comprising liposoluble vitamins like vitamin D3, utilizing a medium chain triglyceride (MCT) oil and triglycerides of caprylic and capric acids, which are compressible and stable, allowing for precise and repeatable dosing without the oily feeling, achieved through a specific weight ratio and heating process to deactivate lipases.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If oily solutions of vitamin D are used in drop form, then the vitamin can be administered, but the administration is difficult and the palatability is poor
Solution Approach 1:
The patent changes the physical parameters of the oily solution by adjusting viscosity through specific triglyceride selection and adding suspending agents, allowing the formulation to be delivered as an aerosol spray rather than drops, fundamentally improving ease of administration and palatability
Solution Approach 2:
The patent replaces the mechanical drop-delivery system with an aerosol spray system that uses pressurized gas to deliver the vitamin formulation as a fine mist, eliminating the need for manual dropper administration and improving patient compliance
2Ease of manufacture
If solid or aqueous dispersions of vitamin D are developed to reduce limitations, then the formulation is easier to handle, but the bioavailability of the vitamin is reduced
Solution Approach 1:
The patent creates a composite oily formulation combining vitamin D with specific triglycerides (medium-chain and long-chain) and suspending agents that maintain the vitamin in a dissolved state while providing sprayable physical properties, achieving both ease of manufacture and high bioavailability
Solution Approach 2:
The patent uses triglycerides as intermediary substances that solubilize the liposoluble vitamin D and allow it to be delivered in a sprayable formulation, maintaining the vitamin's bioavailability while enabling new delivery mechanisms
3Ease of operation
If a sprayable formulation is created, then the ease of administration is improved, but the compressibility of oils under pressure must be achieved
Solution Approach 1:
The patent changes the physical parameters of the oily solution by adjusting viscosity through specific triglyceride selection and adding suspending agents, allowing the formulation to be compressed and sprayed effectively
Solution Approach 2:
The patent utilizes pneumatic principles by incorporating a pressurized aerosol delivery system that forces the oily vitamin formulation through a valve and nozzle, achieving sprayable delivery despite the natural resistance of oil to compression
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The formulation enables easy, precise, and bioavailable administration of vitamin D3, improving palatability and reducing manufacturing costs, with comparable or superior bioavailability to traditional oily drops, and is suitable for all age groups without adverse effects.
Implementation Method 1
A sprayable oily liquid formulation comprising liposoluble vitamins like vitamin D3, utilizing a medium chain triglyceride (MCT) oil and triglycerides of caprylic and capric acids
Implementation Method 2
achieved through a specific weight ratio and heating process to deactivate lipases
Data Source
AI summary
The present invention relates to a sprayable oily composition based on one or more liposoluble vitamins. The present invention further relates to a process for preparing said formulation and to uses thereof as a food supplement or a medical device or a pharmaceutical composition for use in treating subjects suffering from diseases and/or disorders associated to vitamin deficiencies.