Squamous Epithelial Cell Controls for Urine Sediment Analysis
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Solution Overview
Problem
Existing quality control substances for urine sediment analyzers do not effectively address the analysis of squamous epithelial cells present in urine, and there is a need for a reliable and easily available material for such control.
Innovation Solution
Utilizing squamous epithelial cells derived from mammals, particularly from human oral cavity or bovine stomach, as a quality control substance in urine sediment analysis, which are similar in form to human squamous epithelial cells, and can be non-invasively obtained and easily available.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If conventional quality control substances (erythrocytes, leukocytes, non-squamous epithelial cells, abnormal casts, yeast cells, mucus) are used, then quality control can be performed for these sediment items, but quality control cannot be performed for squamous epithelial cells
Solution Approach 1:
The patent uses squamous epithelial cells from bovine stomach or human oral cavity as copies or substitutes for human urinary squamous epithelial cells. These alternative sources provide morphologically similar cells that can be used for quality control without requiring human urine samples, thereby enabling reliable quality control for squamous epithelial cells while maintaining versatility across different applications
2Reliability
If human-derived quality control substances are used, then relevance to human urine analysis is high, but availability and ease of acquisition are limited
Solution Approach 1:
The patent employs squamous epithelial cells from bovine stomach or human oral cavity as disposable quality control materials. These cells can be easily obtained from readily available sources (bovine stomach tissue or oral swabs) and used once, then discarded. This approach maintains relevance to human urine analysis through morphological similarity while dramatically improving ease of acquisition and availability compared to using human urine samples
Data Source
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AI summary
An object of the present disclosure to provide a quality control substance which is used in a urine sediment analyzer, and which is for performing quality control in the analysis of squamous epithelial cells that can be present in urine. The present disclosure achieves the above-described object by using squamous epithelial cells derived from a mammal as the quality control substance to be used in the urine sediment analyzer.