SRF Composition Enhancing Collagen Synthesis for Wound Strength

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Solution Overview

Problem

Current wound healing treatments do not effectively enhance wound strength, texture, and pigmentation, as they fail to increase the synthesis and transport of key molecules such as collagen, adhesion molecules, and elastin to wound sites, leading to inadequate healing and potential re-opening of wounds.

Innovation Solution

A medicinal composition comprising magnesium pyruvate, calcium pyruvate, L-proline, and citrulline, known as the Skin Resuscitation Factor (SRF), which is applied topically to enhance the synthesis, secretion, and transport of adhesion molecules, elastin, and type 1 collagen, thereby increasing wound strength, texture, and pigmentation.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Strength

If standard wound healing treatments are used, then wound closure occurs, but wound strength, texture and pigmentation remain inadequate

Engineering Contradiction:

Improvewound strengthVSAvoidhealing quality

Core Design Contradiction:

StrengthVSReliability

Solution Approach 1:

The patent changes the chemical parameters of the treatment by using magnesium and calcium pyruvate salts instead of conventional treatments, and optimizes the concentration ratios of L-proline and L-citrulline to enhance collagen synthesis and transport, thereby improving wound strength while maintaining healing reliability

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The invention creates a composite therapeutic formulation combining multiple components (magnesium pyruvate, calcium pyruvate, L-proline, and L-citrulline) that work synergistically to enhance collagen production, secretion and transport, resulting in improved wound strength, texture and pigmentation

Inventive Principle:

Principle #40Composite materials

2Productivity

If wound healing is accelerated, then re-epithelialization speed increases, but wound strength decreases allowing wounds to reopen

Engineering Contradiction:

Improvehealing rateVSAvoidwound strength

Core Design Contradiction:

ProductivityVSStrength

Solution Approach 1:

The patent ensures continuous enhancement of collagen synthesis, secretion and transport processes through the sustained action of the pyruvate-amino acid formulation, maintaining both rapid healing and strong wound structure simultaneously by keeping collagen production active throughout the healing process

Inventive Principle:

Principle #20Continuity of useful action

3Quantity of substance

If collagen synthesis is increased, then wound strength improves, but transport of collagen to wound sites remains insufficient

Engineering Contradiction:

Improvecollagen synthesisVSAvoidcollagen transport speed

Core Design Contradiction:

Quantity of substanceVSSpeed

Solution Approach 1:

The patent uses magnesium and calcium pyruvate as intermediary substances that facilitate both collagen synthesis and its subsequent transport to wound sites. The pyruvate salts act as mediators that enhance the cellular mechanisms for both producing and delivering collagen, solving the transport bottleneck

Inventive Principle:

Principle #24Intermediary (Mediator)

Data Source

PatentUS11458114B2Methods and compositions for enhancing synthesis secretion and transport of collagen to increase wound strength

Publication Date: 2022.10.04 NORTH CELL PHARMA INC

AI summary

A method for, and medicinal composition for, treatment of mammalian cells for enhancing synthesis, secretion and transport of collagen to increase wound strength, that includes magnesium pyruvate; calcium pyruvate; L proline; citrulline: and a liquid carrier.