Streptococcus thermophilus ST4 Anti-Inflammatory Efficacy
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Solution Overview
Problem
Current Streptococcus thermophilus strains are not effective in suppressing inflammation and colorectal cancer, and there is a need for a strain that can safely inhibit intestinal inflammation and cancer progression.
Innovation Solution
A novel Streptococcus thermophilus strain ST4, isolated from raw milk, which is effective in treating or preventing inflammatory diseases and colorectal cancer by inhibiting TNF-α production and reducing tumor formation and intestinal inflammation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If common Streptococcus thermophilus strains are used, then probiotic effects are provided, but they cannot suppress inflammation and colorectal cancer
Solution Approach 1:
The patent identifies and utilizes specific biochemical parameters of strain ST4, including its unique cell wall composition (25.3% peptidoglycan, 18.7% teichoic acid, 5.8% lipoteichoic acid) and metabolite profile (lactate, acetate, formate, succinate, ethanol), which differentiate it from common strains and provide enhanced anti-inflammatory and anti-cancer effects
Solution Approach 2:
The patent focuses on specific functional properties of strain ST4, particularly its cell wall components and metabolites, that locally provide anti-inflammatory and anti-cancer activities, rather than relying on general probiotic effects of common strains
2Adaptability or versatility
If Streptococcus gallolyticus or Streptococcus infantarius are present in the intestine, then bacterial flora diversity is maintained, but colorectal cancer risk significantly increases
Solution Approach 1:
The patent utilizes the cell wall components of Streptococcus thermophilus ST4 (peptidoglycan, teichoic acid, lipoteichoic acid) that normally could be pro-inflammatory, but in this specific strain configuration, they exhibit anti-inflammatory effects and inhibit colorectal cancer cell proliferation, converting potential harm into benefit
Solution Approach 2:
The patent identifies metabolites (lactate, acetate, formate, succinate, ethanol) and cell wall components of strain ST4 as intermediary substances that mediate between the bacterial flora and host intestinal cells, preventing the harmful effects of pro-cancerous bacteria while maintaining flora diversity
3Adaptability or versatility
If LPS from Gram-negative bacteria is present, then bacterial presence is normal, but inflammatory response and cancer cell growth are promoted
Solution Approach 1:
The patent demonstrates that strain ST4 converts the typical pro-inflammatory response to bacterial components into an anti-inflammatory effect, where the bacterial cell wall components and metabolites inhibit TNF-α production and reduce inflammatory-mediated cancer cell growth
Solution Approach 2:
The patent shows that strain ST4 exerts preliminary anti-action by pre-inhibiting the inflammatory response pathway before LPS can fully activate cancer cell proliferation, reducing TNF-α production and preventing the cascade that leads to tumor growth
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The novel strain ST4 reduces TNF-α secretion, inhibits colorectal tumor hyperplasia, and alleviates intestinal inflammation, effectively preventing colorectal cancer progression.
Implementation Method 1
The novel Streptococcus thermophilus strain ST4...provides the efficacy in treating or preventing inflammatory diseases or colorectal cancer...inhibiting TNF-α production
Implementation Method 2
The novel Streptococcus thermophilus strain ST4...inhibits colorectal tumor hyperplasia, and alleviates intestinal inflammation, effectively preventing colorectal cancer progression
Data Source
AI summary
The present invention provides a novel Streptococcus thermophilus strain ST4, and its use in manufacturing a medicament and/or food composition for treating and/or preventing an inflammatory disease and/or a cancer.