Stabilized Amorphous Calcium Carbonate for Nerve Regeneration and IVF

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Solution Overview

Problem

Current treatments for nerve injuries, muscular dystrophies like Duchenne muscular dystrophy, and male infertility are inadequate, and there is a need for improved methods in assisted reproductive technology to enhance sperm quality and embryo development.

Innovation Solution

The use of stabilized amorphous calcium carbonate (ACC) to promote nerve fiber regeneration, improve sperm quality, and enhance embryo development through the inclusion in cell culture media.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If stabilized amorphous calcium carbonate (ACC) is used, then nerve fiber regeneration and myotube formation are enhanced, but the complexity of pharmaceutical composition increases

Engineering Contradiction:

Improvenerve fiber regenerationVSAvoidpharmaceutical composition

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

Stabilizing agents (polyphosphates, phosphorylated amino acids, proteins, or polysaccharides) are introduced as intermediary substances that mediate between the ACC and biological systems. These intermediaries prevent ACC crystallization and degradation, enabling controlled calcium release that promotes nerve regeneration and myotube formation without requiring complex formulation systems

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The pharmaceutical composition is formulated as a composite material combining ACC particles with stabilizing agents. This composite structure maintains the amorphous state of calcium carbonate while providing controlled dissolution properties, achieving enhanced regenerative effects through the synergistic interaction between ACC and its stabilizers

Inventive Principle:

Principle #40Composite materials

2Reliability

If stabilized ACC is administered, then calcium bioavailability is enhanced, but the stability of ACC composition becomes challenging to maintain

Engineering Contradiction:

Improvecalcium bioavailabilityVSAvoidACC stability

Core Design Contradiction:

ReliabilityVSStability of the object's composition

Solution Approach 1:

Stabilizing agents act as intermediary substances that prevent the transition of ACC from amorphous to crystalline state. These agents (polyphosphates, phosphorylated amino acids, proteins, or polysaccharides) bind to calcium ions and ACC surfaces, inhibiting crystallization while allowing controlled calcium release in physiological environments, thus maintaining both stability and bioavailability

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The chemical parameters of the ACC composition are modified by incorporating stabilizing agents that change the surface properties and dissolution kinetics of calcium carbonate. These parameter changes include adjusting pH sensitivity, dissolution rate, and crystallization tendency, enabling the ACC to remain stable during storage while enhancing calcium bioavailability upon administration

Inventive Principle:

Principle #35Parameter changes

3Reliability

If ACC is used for sperm motility enhancement, then sperm quality improves, but the precision of dosage control becomes difficult

Engineering Contradiction:

Improvesperm qualityVSAvoiddosage control

Core Design Contradiction:

ReliabilityVSManufacturing precision

Solution Approach 1:

The dosage form is designed by controlling particle size distribution, calcium content, and stabilizer concentration of ACC. These parameter changes enable precise dosage control while maintaining enhanced sperm motility effects. The ACC is formulated with specific surface area and dissolution rate characteristics that ensure reproducible dosing responses

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

ACC accelerates nerve fiber regeneration, improves sperm motility and quality, and increases the number of embryos reaching advanced developmental stages, offering potential therapeutic benefits for nerve injuries, muscular dystrophies, and improved outcomes in assisted reproductive technology.

Implementation Method 1

stabilized amorphous calcium carbonate (ACC) as a pharmaceutical composition, combined with stabilizing agents such as polyphosphates and phosphorylated amino acids

Methodology Applied

Scientific EffectStabilization:

Implementation Method 2

enhance cellular processes including nerve regeneration, myotube formation, and sperm motility, and promote embryo development in vitro

Methodology Applied

Scientific EffectCellular growth and differentiation:

Implementation Method 3

stabilizing calcium bioavailability and promoting cellular growth and differentiation

Methodology Applied

Scientific EffectCalcium bioavailability stabilization:

Data Source

PatentUS12629390B2Stabilized amorphous calcium carbonate for treatment of neurological, muscular and infertility diseases or conditions

Publication Date: 2026.05.19 AMORPHICAL LTD

AI summary

Stabilized amorphous calcium carbonate (ACC) for treatment of several neurological, muscular and infertility diseases and conditions is provided. In particular, the stabilized ACC may be used in the treatment of axonal defects and muscular dystrophy. In addition, provided are improved methods used in assistant reproductive technology. Examples of such methods are in vitro fertilization and improvement of sperm quality. The improved IVF method, for example, comprises addition of the stabilized ACC to the cell culture medium in which the stages of fertilization and embryo development occurs.