Stabilized Calcium Phosphate with Pendant Polymerizable Groups
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Solution Overview
Problem
Existing calcium phosphate materials used in dental and biomedical applications face challenges such as instability in acidic conditions, limited mechanical strength, and poor compatibility with monomers, which restricts their use in load-bearing applications and restorative dentistry.
Innovation Solution
A method of forming stabilized calcium phosphate by reacting a calcium salt with an organic phosphate having a polymerizable methacrylate or vinyl group, such as bis[2-(methacryloyloxy)ethyl] phosphate, and an inorganic phosphate source, resulting in a calcium phosphate with pendant polymerizable groups that enhances stability and bioactivity, allowing integration with resin systems and improved mechanical properties.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If amorphous calcium phosphate is used in dental restorative materials, then it can release calcium and phosphate ions for remineralization, but it turns into hydroxyapatite when in contact with water, losing its stability
Solution Approach 1:
The patent creates a composite material consisting of calcium phosphate particles dispersed in a polymer matrix. The polymer component provides structural stability and prevents premature transformation of the amorphous calcium phosphate into hydroxyapatite, while still allowing controlled ion release for dental remineralization applications
Solution Approach 2:
The patent modifies the physical and chemical parameters of the calcium phosphate by controlling particle size, surface area, and dispersion characteristics within the polymer matrix. These parameter changes enhance stability while maintaining bioactivity and ion release capabilities
2Stability of the object's composition
If crystalline hydroxyapatite is produced by high temperature sintering, then it achieves high crystallinity and structural stability, but it has limited solubility and reduced resorbability
Solution Approach 1:
The patent produces calcium phosphate particles with controlled crystallinity through wet chemical methods rather than high-temperature sintering. By controlling parameters such as pH, temperature, and reaction time during synthesis, the patent achieves a balance between crystalline structure and solubility, enabling both stability and resorbability for biomedical applications
Solution Approach 2:
The patent creates particles with heterogeneous internal structure, where the core maintains crystalline order for stability while the surface retains higher solubility characteristics. This local quality variation allows simultaneous achievement of structural integrity and controlled resorption in the body
3Reliability
If calcium phosphate materials are used in load-bearing applications, then they provide good tissue compatibility, but they have limited mechanical strength
Solution Approach 1:
The patent develops composite materials combining calcium phosphate particles with polymer matrices or other reinforcing phases. This composite structure provides both the biocompatibility of calcium phosphate and enhanced mechanical strength from the polymer or reinforcement, making the material suitable for load-bearing biomedical applications
Solution Approach 2:
The patent creates porous calcium phosphate structures with controlled pore size and distribution. The porous architecture reduces overall density and can improve mechanical properties through optimized load distribution, while maintaining high surface area for bone ingrowth and tissue compatibility
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The stabilized calcium phosphate exhibits higher stability, mechanical strength, and bioactivity, enabling effective use in polymerizable resin systems, bioactive fillers for dental restoratives, and bone substitutes, with enhanced ion release and bone growth promotion.
Implementation Method 1
reacting a calcium salt with an organic phosphate having a polymerizable methacrylate or vinyl group
Implementation Method 2
organic phosphate having a polymerizable methacrylate or vinyl group
Data Source
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AI summary
A method of forming a stabilized calcium phosphate moiety for use in dental or biomedical applications includes providing a solution or dispersion including a calcium salt and reacting an organic phosphate having a polymerizable methacrylate or vinyl group with the solution or dispersion in order to form the calcium phosphate moiety having at least one pendant polymerizable group and at least one organic functional group, which may be the same group. A polymerizable composite system having a stabilized calcium phosphate formed according to the method is also provided.