Stabilized Spirulina Extract Composition for Cardiovascular Support
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Solution Overview
Problem
Current spirulina-based food supplements are ineffective at lower doses and have variable nutritional effects due to the lack of selection based on metabolic profile, with high doses being unacceptably high and not guaranteeing consistent benefits for cardiovascular support or sports performance.
Innovation Solution
A stabilized spirulina extract composition with a titrated content of phycobiliproteins and natural oligopeptides, where the oligopeptides have a molecular weight lower than 2500 Dalton, is developed to ensure synergistic effects and improved absorption, using a method that prevents enzymatic degradation and ensures consistent bioactive compound presence.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If high doses of whole spirulina are used, then cardiovascular support and sports performance benefits are achieved, but the dose becomes unacceptably high and variability in effects persists
Solution Approach 1:
The patent extracts and isolates specific bioactive compounds (phycocyanins and oligopeptides) from whole spirulina biomass. This extraction process concentrates the active ingredients, allowing effective doses to be reduced from grams of whole spirulina to milligrams of purified compounds, thereby resolving the contradiction between achieving therapeutic effects and maintaining acceptable dose levels.
Solution Approach 2:
The patent applies local quality by selectively enriching the composition with specific bioactive compounds (phycocyanins and oligopeptides) rather than using whole spirulina. This targeted approach ensures consistent delivery of proven effective compounds, eliminating the variability associated with whole spirulina while reducing the required dose.
2Ease of manufacture
If endogenous proteases are allowed to act on spirulina extract, then protein hydrolysis occurs, but the content of natural oligopeptides is reduced in a few days
Solution Approach 1:
The patent applies preliminary anti-action by adding protease inhibitors to the spirulina extract during preparation. This prevents endogenous proteases from degrading the oligopeptides, thereby maintaining their stability and content over time without requiring complex purification or freezing processes.
Solution Approach 2:
The patent uses protease inhibitors as intermediary substances that mediate between the endogenous proteases and the oligopeptides. These inhibitors block the harmful enzymatic activity while allowing the beneficial oligopeptides to remain stable, resolving the contradiction between simple preparation and composition stability.
3Adaptability or versatility
If variable metabolic profiles of spirulina samples are used, then different nutritional effects are observed, but consistency in bioactive compound content cannot be guaranteed
Solution Approach 1:
The patent changes the parameter of composition standardization by defining specific minimum content thresholds for phycocyanins and oligopeptides. This parameter-based approach ensures that all batches meet consistent quality standards regardless of natural variability in spirulina samples, thereby guaranteeing reproducible benefits while maintaining adaptability through the range of acceptable compositions.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The stabilized spirulina extract composition provides effective cardiovascular support and enhanced sports performance with lower doses, ensuring consistent bioactive compound presence and improved absorption, addressing the variability and acceptability issues of existing supplements.
Implementation Method 1
A stabilized spirulina extract composition with a titrated content of phycobiliproteins and natural oligopeptides, where the oligopeptides have a molecular weight lower than 2500 Dalton, is developed to ensure synergistic effects and improved absorption
Data Source
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Figure 3A~3B
Figure 3C~4
AI summary
Composition based on stabilized spirulina extract comprising phycobiliproteins and a titrated content of a fraction of natural oligopeptides natively present in the spirulina having a molecular weight lower than 2500 Dalton.