Stabilized Stannous Ion Emulsion for High-Water Oral Care
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Solution Overview
Problem
Stannous ions in high-water oral care products are prone to dissociation, leading to hydrolysis, chelation, oxidation, and precipitation, which deteriorate their anti-plaque, anti-caries, and anti-allergy effects, and result in poor esthetics and weakened flavor impact.
Innovation Solution
A method involving the formation of a stable stannous ion complex through a multi-phase emulsion process, combining aqueous and oil phases with specific ratios of water, stannous ions, chelating agents, and emulsifiers, followed by re-dispersion to create a W/O/W stannous ion composition.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If stannous ions are used in high-water oral care products, then the anti-plaque, anti-caries, and anti-allergy effects are improved, but the stannous ions are easily dissociated and undergo hydrolysis, chelation, oxidation, and precipitation, deteriorating their effectiveness
Solution Approach 1:
The patent introduces an intermediary complex formation mechanism where stannous ions are stabilized through coordination with specific molecules in the aqueous phase, preventing direct dissociation and unwanted chemical reactions. This intermediary complex acts as a protective carrier that maintains stannous ion stability in high-water formulations.
Solution Approach 2:
The patent modifies the chemical environment parameters of the aqueous phase, including pH, ionic strength, and composition, to optimize stannous ion stability. By controlling these parameters, the formulation prevents hydrolysis, chelation, oxidation, and precipitation while maintaining the anti-plaque, anti-caries, and anti-allergy effects.
2Stability of the object's composition
If low-water or anhydrous formulations are used for stannous ions, then the stannous ion stability is improved, but the esthetics, foam, and flavor impact are deteriorated
Solution Approach 1:
The patent changes the water content parameter from low-water/anhydrous to high-water formulation, while simultaneously adjusting other formulation parameters (aqueous phase composition, emulsifier ratios, aging time) to compensate for the increased dissociation risk, thereby achieving both stability and improved product properties.
Solution Approach 2:
The patent incorporates a preliminary aging step during formulation development to pre-stabilize the stannous ion complex before final product use. This preliminary action allows the system to reach a stable state that maintains effectiveness in high-water formulations, preventing issues during actual use.
3Ease of operation
If high-water content formulations are used, then the esthetics, foam, and flavor impact are improved, but the stannous ions are prone to dissociation and chemical changes
Solution Approach 1:
The patent uses an intermediary complex formation mechanism where stannous ions are stabilized through coordination with specific molecules in the aqueous phase, preventing direct dissociation and unwanted chemical reactions. This intermediary complex acts as a protective carrier that maintains stannous ion stability in high-water formulations.
Solution Approach 2:
The patent ensures continuous stability of stannous ions throughout the product shelf life by incorporating stabilization mechanisms that remain active from formulation through storage and use. The aqueous phase composition and emulsifier system continuously protect against dissociation and chemical changes, maintaining anti-plaque, anti-caries, and anti-allergy effects throughout the product lifecycle.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method achieves a stable stannous ion emulsion with high Sn2+ retention and antibacterial efficacy, maintaining effectiveness in oral care products like toothpaste and mouthwash, with stability and antibacterial properties exceeding 90% after aging tests.
Implementation Method 1
stannous ions are easily dissociated in a dentifrice formulation and thus engages in complex chemical changes including hydrolysis, chelation, oxidation, and precipitation
Implementation Method 2
combining equal parts of the first aqueous phase and the oil phase to form water in oil (W/O) emulsion
Implementation Method 3
stannous ions are easily dissociated in a dentifrice formulation and thus engages in complex chemical changes including hydrolysis, chelation, oxidation, and precipitation
Data Source
AI summary
A stable stannous ion emulsion complex formed from combining a first aqueous phase with an oil phase to form a water in oil emulsion; forming a second aqueous phase; and combining the second aqueous phase with the water in oil emulsion. The first aqueous phase including water, stannous ions, a chelating agent, and a pH buffer. The oil phase including an oil and a first emulsifier. The water in oil emulsion including equal amounts of the oil phase and the first aqueous phase. The second aqueous phase including water, stannous ions, a chelating agent, a pH buffer, and a second emulsifier.