Stable Antioxidant Compositions Using Propanediol Solvents
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Solution Overview
Problem
Current antioxidant compositions struggle to maintain neohesperidin dihydrochalcone in a stable, reduced state, limiting its incorporation in cosmetic formulations due to ease of oxidation, and existing products on the market only achieve a maximum of 0.613% stability in emulsions.
Innovation Solution
Developing antioxidant compositions that include high amounts of stabilized neohesperidin dihydrochalcone, along with additional antioxidants like ferulic acid and tocopherols, using water-soluble solvents such as propanediol, and emulsifiers to create stable emulsions that maintain the antioxidants in a reduced state, ensuring effective skin protection.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If high amounts of neohesperidin dihydrochalcone are incorporated into cosmetic formulations, then antioxidant effectiveness is improved, but stability is worsened due to ease of oxidation
Solution Approach 1:
The patent uses ferulic acid and tocopherols as intermediary substances that mediate between neohesperidin dihydrochalcone and oxygen, preventing direct oxidation of the active ingredient while maintaining antioxidant effectiveness through synergistic action
Solution Approach 2:
The patent changes the chemical state parameters of neohesperidin dihydrochalcone by maintaining it in a reduced form through careful control of pH, water activity, and oxidation potential, allowing high incorporation levels while preventing oxidation
2Reliability
If neohesperidin dihydrochalcone is maintained in a reduced state, then antioxidant activity is improved, but manufacturing and storage stability is worsened
Solution Approach 1:
The patent applies preliminary protective measures during manufacturing by incorporating antioxidants and chelating agents into the formulation before exposure to oxidation conditions, ensuring the active ingredient remains in a reduced state throughout production and storage
Solution Approach 2:
The patent creates an inert chemical environment by using antioxidants that scavenge oxygen and chelating agents that bind metal ions, effectively creating a protective atmosphere that prevents oxidation of neohesperidin dihydrochalcone during manufacturing and storage
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The compositions effectively protect skin from environmental stressors and aging, providing significant antioxidant properties that improve skin radiance, tone, and overall appearance, while maintaining stability for extended periods without phase separation or crystallization.
Implementation Method 1
The compositions include at least 20 wt. % of one or more water-soluble solvents, such as propanediol, which contribute to the surprising solubility and stability of the compositions
Implementation Method 2
Antioxidants are chemicals and biologicals that destroy harmful oxygen free radicals. Antioxidants scavenge oxidation of cells caused by oxygen free radicals, thereby preventing cell damage
Data Source
AI summary
The present disclosure relates to antioxidant compositions comprising a high amount of stabilized neohesperidin dihydrochalcone. The antioxidant compositions may further include additional antioxidants, such as ferulic acid, and tocopherols. The compositions include at least 20 wt. % of one or more water-soluble solvents, such as propanediol, which contribute to the surprising solubility and stability of the compositions. The antioxidant properties of the compositions make them particularly effective for treating and protecting the skin. For example, the compositions are useful for protecting the skin from environmental insult.