Cardiovascular Composition for Stable Probiotic Cholesterol Management
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Solution Overview
Problem
Existing treatments, such as statin drugs, often fail to effectively manage cholesterol levels in individuals, and there is a need for a stable composition that can reduce LDL cholesterol and CRP levels while promoting cardiovascular health.
Innovation Solution
A composition comprising 10%-70% Lactobacillus plantarum or Lactobacillus reuteri, 2%-86% plant sterols, and 4%-88% Ashwagandha root powder, which is storage-stable for at least 6 months, administered to individuals for at least 12 weeks.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If statin drugs are used to reduce cholesterol, then cholesterol levels are reduced, but treatment effectiveness is insufficient for some patients and heart disease remains prevalent
Solution Approach 1:
The patent combines three distinct components (probiotics, plant sterols, and Ashwagandha root powder) into a composite dietary supplement formulation. This composite approach leverages the synergistic effects of each component: probiotics for gut health and cholesterol metabolism, plant sterols for direct cholesterol absorption inhibition, and Ashwagandha for cardiovascular protection and inflammation reduction, thereby achieving more reliable cholesterol management than single-component solutions.
2Reliability
If probiotics are used to reduce LDL cholesterol and CRP, then cardiovascular outcomes improve, but long-term storage stability is compromised
Solution Approach 1:
The patent employs parameter changes by selecting specific probiotic strains (Lactobacillus plantarum and Lactobacillus reuteri) and optimizing their concentration ranges (10%-70% of total composition). Additionally, the combination with plant sterols and Ashwagandha root powder creates a microenvironment that protects bacterial viability during storage, allowing the product to maintain effectiveness for at least 6 months while preserving cardiovascular health benefits.
3Reliability
If plant sterols are used to reduce cholesterol absorption, then circulating cholesterol levels decrease, but the structural similarity to cholesterol complicates absorption mechanisms
Solution Approach 1:
The patent uses plant sterols as intermediary substances that structurally resemble cholesterol but are not absorbed in the same manner. These plant sterols (β-sitosterol, campesterol, stigmasterol) act as mediators by competing with cholesterol for absorption in the intestinal tract, thereby reducing cholesterol absorption without being incorporated into cell membranes like cholesterol, thus simplifying the overall absorption mechanism while maintaining effectiveness.
4Reliability
If Ashwagandha root powder is used to decrease inflammation and cholesterol, then cardiovascular health improves, but formulation stability over time is challenged
Solution Approach 1:
The patent formulates Ashwagandha root powder (4%-88% of composition) in combination with probiotics and plant sterols to create a stable composite dietary supplement. This composite formulation protects the bioactive compounds in Ashwagandha (withanolides) from degradation during storage while maintaining their anti-inflammatory and cholesterol-lowering effects, achieving formulation stability for at least 6 months.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively reduces LDL cholesterol and CRP levels, promotes a healthy gut microbiome, and enhances cardiovascular health by maintaining bacterial viability and synergistic activity over an extended period.
Implementation Method 1
Probiotics are beneficial bacteria, two strains of which, L. plantarum and L. reuteri have been demonstrated to reduce LDL cholesterol levels and reduce C-reactive protein (CRP)
Implementation Method 2
there is evidence that plant sterols reduce cholesterol absorption and thus reduce circulating levels of cholesterol
Implementation Method 3
Ashwagandha is used in traditional medicines to decrease inflammation, cortisol-related anxiety and cholesterol
Data Source
AI summary
Described herein is a composition comprising a unique and novel combination of natural ingredients supporting cardiovascular health by contributing to healthy serum cholesterol levels while also reducing CRP and IL-6 cytokine levels. Furthermore, the composition promotes the development of a healthy or healthier gut microbiome. The composition comprises 10%-70% Lactobacillus plantarum, Lactobacillus reuteri and mixtures thereof; 2%-86% plant sterols; and 4%-88% Ashwagandha root powder.