Standardized Valerian Composition for Sleep Quality Improvement
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Solution Overview
Problem
There is a need for effective and convenient solutions for sleep-related disorders, particularly insomnia, which are not adequately addressed by existing medications, and there is a lack of standardized and efficient methods for extracting valerian extracts that maximize beneficial compounds like valerenic acids while minimizing valepotriates.
Innovation Solution
A valerian composition comprising valerian extract with specific ratios of valerenic acids, hydroxy valerenic acid, and acetoxy valerenic acid, formulated with pharmaceutically and nutraceutically acceptable excipients, is developed in various dosage forms, and a method for extraction and preparation is optimized to enhance sleep-promoting effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If conventional extraction methods are used for valerian, then the extraction process is simple, but the yield of beneficial compounds (valerenic acids) is low and harmful compounds (valepotriates) are not minimized
Solution Approach 1:
The patent applies parameter changes by optimizing extraction conditions including using specific solvent systems (ethanol-water mixtures), controlling extraction temperature, and adjusting extraction time to maximize valerenic acid yield while minimizing valepotriate decomposition. The extraction process uses controlled parameters to achieve selective extraction of desired compounds.
Solution Approach 2:
The patent employs composite extraction systems using mixed solvents (ethanol and water in specific ratios) to enhance extraction efficiency. This composite approach allows simultaneous extraction of different compounds with varying polarities, improving overall yield of valerenic acids while maintaining selectivity.
2Reliability
If valerian extract is standardized to contain specific compounds, then the efficacy for sleep disorders is improved, but the manufacturing precision requirements increase
Solution Approach 1:
The patent implements feedback control through standardized analytical methods to monitor and adjust the composition of valerian extract. By establishing feedback loops that measure actual compound concentrations and compare them against target specifications, the manufacturing process can be adjusted to achieve consistent standardization of valerenic acid content across batches.
Solution Approach 2:
The patent uses parameter changes to standardize the extract by controlling key parameters such as extraction solvent composition, extraction time, and temperature. These controlled parameter changes ensure consistent production of extract with standardized concentrations of valerenic acids, hydroxy valerenic acid, and acetoxy valerenic acid.
3Ease of operation
If existing medications are used for insomnia, then sleep induction may be achieved, but side effects and limited efficacy evidence exist
Solution Approach 1:
The patent applies the extraction principle by isolating and concentrating the beneficial compounds (valerenic acids, hydroxy valerenic acid, and acetoxy valerenic acid) from the whole valerian plant material. This extraction creates a standardized, purified product that delivers the therapeutic effects of valerian while removing or minimizing unwanted components that could cause side effects.
Solution Approach 2:
The patent implements local quality by creating a highly concentrated extract with specific, controlled compositions of active compounds. Rather than using crude plant material with variable and unpredictable composition, the localized concentration of proven beneficial compounds provides consistent efficacy with reduced risk of adverse effects from other plant constituents.
Data Source
AI summary
The present invention is related to the valerian composition and/or valerian extract for prevention, improvement, and maintenance of sleep disorders and/or sleep management per se improve the quality sleep, improves time to sleep, improves sleep duration, reduces sleep disturbances, maintain healthy stress levels to a subject in need thereof. A valerian composition comprising of the valerian extract and at least one pharmaceutically and/or nutraceutically accepted excipients. The present invention further encompasses the valerian composition wherein further formulated in different forms like powder, beadlets, granules, capsules, tablets, oil suspension, films or any other suitable oral or topical dosage forms using pharmaceutically and/or nutraceutically acceptable excipients.