Oral Care Compositions Stabilizing Stannous Ions with Dentate Ligands
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Solution Overview
Problem
Stannous fluoride in oral care compositions is challenging to formulate due to reactivity with other components, leading to either under-stabilization or over-stabilization, which reduces the availability of bioactive stannous ions.
Innovation Solution
An oral care composition comprising a mixture of dentate ligands, including a first polydentate ligand such as oxalic acid and a monodentate ligand like lactic acid, with a stannous ions to ligand ratio in the range of 1:3 to 1:4, optimized to stabilize stannous ions while maintaining their reactivity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Stability of the object's composition
If stannous fluoride is stabilized with chelants in oral care compositions, then stability of stannous ions is improved, but availability of bioactive stannous ions deteriorates
Solution Approach 1:
The invention segments the chelating function into two distinct components: a polydentate ligand (providing at least 3 carboxylate groups) and a monodentate ligand (providing 1 carboxylate group). This segmentation allows the polydentate ligand to provide structural stability through multiple binding sites while the monodentate ligand modulates the complex to maintain bioavailability, resolving the contradiction between stability and availability
Solution Approach 2:
The invention creates a composite chelating system combining polydentate and monodentate ligands in specific molar ratios (0.5:1 to 2:1 polydentate:monodentate). This composite approach leverages the strong binding capability of polydentate ligands for stability while the monodentate component prevents excessive stabilization, maintaining the balance between stability and bioavailability of stannous ions
2Reliability
If stannous fluoride is formulated with carboxylate-containing compounds, then reactivity with other components is reduced, but amount of available stannous ions decreases
Solution Approach 1:
The invention optimizes the molar ratio parameters of polydentate to monodentate ligands (specifically 0.5:1 to 2:1 ranges) to achieve the desired balance. By adjusting these stoichiometric parameters, the formulation controls the degree of chelation to provide sufficient stability against unwanted reactions while maintaining adequate availability of stannous ions for oral care benefits
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition achieves optimal bioavailability and stability of stannous ions, enhancing hydroxyapatite protection against citric acid challenge and improving fluoride uptake, thereby providing effective oral care benefits.
Implementation Method 1
a mixture of dentate ligands comprising: i. a first polydentate ligand, wherein the first polydentate ligand is oxalic acid, a salt thereof, or a combination thereof; and ii. a monodentate ligand, wherein the monodentate ligand is lactic acid or a salt thereof
Implementation Method 2
The stannous ion source can deposit on the tooth surfaces creating an acid-resistant coating that helps the teeth resist dissolution from dietary acids
Implementation Method 3
They can also include a fluoride source that helps the teeth resist plaque acids for the prevention of cavities. Stannous fluoride provides both stannous and fluoride ions for the protection of teeth from dietary and plaque acids
Data Source
AI summary
Oral care compositions are disclosed comprising a mixture of dentate ligands including mono-, di- and/or tetracarboxylic acid(s) as well as a stannous ion source and a fluoride ions source, such as stannous fluoride. Said oral care compositions show an ability to prevent and/or treat dental erosion and/or carics.