Modified Starch Hydrogel for Bone Graft Delivery
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Solution Overview
Problem
Current bone graft materials, such as autogenous bone grafts, face challenges including donor site morbidity, insufficient quantity, and undesirable surgical outcomes due to issues with malleability, viscosity, and adhesiveness, necessitating the development of alternative biocompatible and bioabsorbable materials for effective wound healing.
Innovation Solution
A method involving the use of biocompatible modified starch particles, modified by carboxylation or hydroxylation of glucose units, combined with biological materials to form a mixture that is applied to wounded tissues, providing improved handling, adhesion, and bioabsorption properties for enhanced wound healing.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If autogenous bone graft material is harvested from the patient, then the bone graft provides biocompatibility and osteogenic factors, but it requires a separate surgical incision and causes donor site morbidity and pain
Solution Approach 1:
The patent uses modified starch particles as an intermediary carrier material that delivers osteogenic factors and bone-forming cells to the wound site without requiring harvest from the patient's own bone. The starch particles act as a biocompatible scaffold that mediates bone regeneration while avoiding donor site morbidity associated with autogenous grafts
2Ease of manufacture
If bone dust is used as bone graft material, then it is readily available from surgical waste, but it lacks sufficient malleability, viscosity, and adhesiveness for proper application and retention
Solution Approach 1:
The patent creates a composite material by combining bone dust with modified starch particles. This composite formulation provides the availability of bone dust while the starch matrix imparts the necessary malleability, viscosity, and adhesiveness for proper surgical handling, application, and retention at the wound site
3Reliability
If bone graft material is applied to wounded tissue, then it supports bone formation, but it may not stay in place leading to heterotopic ossification and undesirable surgical outcomes
Solution Approach 1:
The patent modifies the physical and chemical parameters of the starch particles through carboxylation and hydroxylation to enhance their adhesive properties and viscosity. These parameter changes enable the bone graft material to remain stable and in place at the wound site, preventing migration that would cause heterotopic ossification while maintaining osteogenic efficacy
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The modified starch particles create a malleable and cohesive composition that facilitates better placement and retention of biological materials at the wound site, promoting tissue healing by supporting cell migration and releasing bioactive molecules, thereby addressing the limitations of existing bone graft materials.
Implementation Method 1
a composition comprising biocompatible modified starch particles, wherein the starch particles are modified by carboxylation or hydroxylation of glucose units in the starch
Data Source
AI summary
The present disclosure relates to delivering a biological material to a wounded tissue of a patient by the application of a composition comprising biocompatible modified starch particles modified by carboxylation or hydroxylation of glucose units in the starch. Compositions comprising biocompatible modified starch particles are also provided.