Starfish Collagen Peptide Extraction via Alkaline Treatment and Liposomal Encapsulation
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Solution Overview
Problem
Current methods for obtaining collagen peptides from marine organisms, such as starfish, face challenges in extraction efficiency and skin absorption due to the limited availability of marine organisms and the complexity of starfish composition, which includes bone fragments and calcium carbonate, making it difficult to achieve effective collagen extraction and skin penetration.
Innovation Solution
A method involving treating starfish with an alkaline solution to remove non-collagen substances, followed by acid extraction using tartaric acid and ascorbic acid, and subsequent hydrolysis with proteolytic enzymes to produce a low molecular weight collagen peptide, which is then encapsulated in elastic liposomes for enhanced skin absorption.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If collagen is extracted from marine organisms, then it provides an alternative to animal collagen for halal market and safety reasons, but extraction efficiency is lower and extractable marine organisms are limited
Solution Approach 1:
The patent optimizes extraction parameters including using 0.05-0.5% acid compound concentration, controlling pH at 2-3, and setting extraction temperature at 4-25°C to maximize collagen extraction efficiency from starfish while maintaining safety and halal compliance
Solution Approach 2:
The patent uses a composite extraction system combining multiple acid compounds (tartaric acid, ascorbic acid, and/or citric acid) to enhance collagen extraction efficiency from starfish, achieving both safety requirements and improved productivity
2Reliability
If collagen peptides are applied to skin, then they may provide anti-aging benefits, but protein polymers cannot penetrate the stratum corneum effectively
Solution Approach 1:
The patent hydrolyzes collagen into low molecular weight peptides (1,000-5,000 Da) by breaking down the protein polymer structure, enabling the segmented peptide molecules to penetrate the stratum corneum and deliver anti-aging effects to the skin
Solution Approach 2:
The patent controls the molecular weight of collagen peptides to be 1,000-5,000 Da through enzymatic hydrolysis, transforming the size parameter to enable skin penetration while maintaining the bioactivity necessary for anti-aging effects
3Productivity
If starfish are used as a resource, then they solve environmental problems and provide abundant raw material, but their complex composition including bone fragments and calcium carbonate complicates collagen extraction
Solution Approach 1:
The patent performs preliminary treatment of starfish by drying and grinding them into fine powder before extraction, and pre-adjusts the pH of the acid compound solution to 2-3, simplifying the subsequent collagen extraction process despite the complex composition of starfish
Solution Approach 2:
The patent optimizes extraction parameters including acid compound concentration (0.05-0.5%), pH (2-3), and temperature (4-25°C) to efficiently extract collagen from starfish while managing the complexity introduced by bone fragments and calcium carbonate
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method results in a collagen peptide with improved skin absorption and antioxidative properties, effectively addressing the limitations of existing collagen extraction methods by increasing transdermal absorption and providing a cosmetic composition for anti-oxidation and wrinkle improvement.
Implementation Method 1
treating a starfish with an alkaline solution to remove non-collagen substances
Implementation Method 2
adding the starfish from which the non-collagen substances were removed, into an acid solution containing one or more acid compounds of tartaric acid, ascorbic acid and citric acid to extract collagen
Implementation Method 3
adding a proteolytic enzyme to the extracted collagen to hydrolyze the extracted collagen
Implementation Method 4
an elastic liposome comprising a starfish-derived collagen peptide, and a cosmetic composition for improving skin wrinkles that has excellent skin absorption
Data Source
AI summary
A method for obtaining a collagen peptide from a starfish, an elastic liposome containing a starfish-derived collagen peptide, and a cosmetic composition containing the same are disclosed. Methods of using the collagen peptide or the elastic liposome are disclosed. The collagen peptide obtained from a starfish has excellent skin absorption rate and having anti-oxidation and wrinkle-improving activity. Thus, the collagen peptide may replace existing animal collagen to provide collagen with high extraction efficiency.