Stem Cell Angiogenesis Inhibition via Intermediary Mediators
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Solution Overview
Problem
Current treatments for angiogenesis-related disorders, such as cancer and ocular diseases, lack effective methods to inhibit excessive and abnormal neovascularization, leading to tissue damage and vision loss.
Innovation Solution
Administering stem cells or their progeny, specifically mesenchymal precursor cells, which are TNAP+, STRO-1+, VCAM-1+, and CD146+, to regulate angiogenesis and deliver anti-cancer agents, thereby inhibiting the formation of new blood vessels in affected tissues.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional treatments are used for angiogenesis-related disorders, then existing therapeutic approaches are applied, but they fail to effectively inhibit excessive neovascularization
Solution Approach 1:
The patent uses angiostatin, a naturally occurring protein fragment, as an intermediary substance to mediate the inhibition of angiogenesis. This mediator specifically targets and blocks the angiogenic process without affecting normal physiological functions, thereby resolving the contradiction between maintaining treatment reliability and preventing harmful neovascularization
Solution Approach 2:
The invention extracts and utilizes the specific anti-angiogenic activity from complex natural sources (plasminogen activator inhibitor-1 complex) to isolate the therapeutic effect. By taking out only the necessary anti-angiogenic component, the treatment achieves effectiveness while avoiding side effects associated with broader therapeutic approaches
2Productivity
If new blood vessels form to feed diseased tissues, then tumor growth is supported, but tissue damage and vision loss occur
Solution Approach 1:
The patent applies preliminary anti-action by administering angiostatin before excessive neovascularization can cause significant tissue damage. The treatment preemptively blocks the formation of new blood vessels that would otherwise feed tumor growth and cause harmful effects, thereby preventing both tumor progression and tissue damage
Data Source
AI summary
The present invention relates to methods of treating or preventing angiogenesis-related diseases by the administration of stem cells and/or progeny cells thereof.