Stem Cell Infusion Pump with Anionic Film
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Solution Overview
Problem
Traditional infusion pumps cause stem cells to adhere to the inner walls of the liquor storage cavity and infusion pipes, leading to a significant reduction in infusion effectiveness and waste of precious cells.
Innovation Solution
A special infusion pump for stem cells featuring a liquor storage device with an anionic protective film on its inner walls and infusion pipe, made from silicon rubber, which uses the elastic recoil of the storage sac to drive infusion and includes a one-way check valve and anticoagulation layers to prevent cell adhesion and ensure safety and sanitation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a traditional infusion pump is used for stem cell infusion, then the infusion pump can deliver the stem cells, but the stem cells will adhere to the inner wall of the liquor storage cavity and the infusion pipe, causing a significant reduction in infusion effectiveness
Solution Approach 1:
An anionic protective film is introduced as an intermediary layer between the stem cells and the inner wall of the liquor storage cavity and infusion pipe. This film prevents direct contact between the stem cells and the surface, eliminating the adhesion problem while allowing the infusion pump to function normally.
Solution Approach 2:
The surface charge of the inner wall is changed from neutral or positive to negative by applying an anionic protective film. This parameter change in surface charge creates electrostatic repulsion against the negatively charged stem cell membranes, preventing adhesion and maintaining cell viability during infusion.
2Strength
If the liquor storage sac is made rigid to maintain structure, then the structural integrity is improved, but the ability to use elastic recoil for infusion is reduced
Solution Approach 1:
The liquor storage sac is constructed from flexible silicon rubber material that can deform elastically. This flexible shell allows the sac to be compressed for filling and then use its elastic recoil to drive the infusion process, eliminating the need for complex external pumping mechanisms while maintaining structural integrity.
Solution Approach 2:
The liquor storage sac transitions from a static rigid structure to a dynamic flexible structure that can change shape and volume. The sac is designed to be compressible during filling and then automatically expands using elastic recoil to propel the stem cell suspension through the infusion pipe, creating a self-regulating infusion system.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The anionic protective film reduces stem cell loss by repelling cells from the inner surfaces, enhancing infusion efficiency and maintaining the viability of stem cells during administration.
Implementation Method 1
the inner wall of the liquor storage sac and the infusion pipe is provided with a layer of anionic protective film
Implementation Method 2
the liquor storage sac is made of silicon rubber, so that the liquor storage sac has good elasticity, and the physic liquor is infused into the body of a patient using the recoil of the liquor storage sac
Data Source
AI summary
The infusion pump for stem cells includes a liquor storage device and an infusion pipe. The inner wall of the liquor storage sac of the liquor storage device and inner walls of the infusion pipe are provided with an anionic protective film to prevent stem cells from adhering to the infusion pump by mutual repulsion between anions. The infusion method includes checking an infusion pump for integrity, losing a liquor stop clamp, injecting a mixed liquor of stem cells and medicine, covering a protective cap, opening the liquor stop clamp, closing the liquor stop clamp for use, connecting an external cone joint with a venous cannula, and then opening the liquor stop clamp. The method also includes steadily placing the liquor storage sac on a horizontal plane using an auxiliary placing device, and after infusion ends, closing the liquor stop clamp, and disconnecting the external cone joint.