Intravascular Stent Cell Adherence via Dynamic Suspension Flow
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Solution Overview
Problem
Existing methods for manufacturing stents struggle with insufficient cell adherence, which affects the endothelialization ability of the stent.
Innovation Solution
A method involving a cylindrical holder and an outer cylinder is used to culture vascular endothelial cells or progenitor cells on the stent, ensuring sufficient adherence by flowing the cell suspension while in contact with the stent.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If cells are cultured on a stent surface using conventional static methods, then the manufacturing process is simple, but cell adherence is insufficient and endothelialization ability is reduced
Solution Approach 1:
The patent transforms the static cell culture method into a dynamic flow-based system. The culture container is designed to allow cell suspension to flow over the stent surface, creating dynamic contact between cells and stent. This flow mechanism significantly improves cell adherence and endothelialization ability compared to static culture methods, while maintaining a relatively simple overall device structure.
Solution Approach 2:
The patent utilizes hydraulic principles by introducing cell suspension flow through the culture container. The flowing suspension creates hydrodynamic contact with the stent surface, enhancing cell deposition and adherence. This hydraulic approach replaces static incubation with active fluid-driven cell delivery, directly addressing the insufficient cell adherence problem.
2Area of stationary object
If cell suspension is supplied in a static manner, then the culture method is simple to operate, but cell adherence coverage is limited
Solution Approach 1:
The patent implements dynamic flow of cell suspension through the culture container, causing the suspension to continuously move over the stent surface. This dynamic approach ensures comprehensive coverage of the stent surface with adhered cells, expanding the cell adherence area beyond what static methods can achieve. The flow mechanism is integrated into the container design, maintaining ease of operation.
3Reliability
If conventional stent manufacturing methods are used, then the manufacturing process is straightforward, but cell adherence is insufficient affecting endothelialization
Solution Approach 1:
The patent employs hydraulic flow of cell suspension to achieve uniform distribution of cells across the stent surface. The flowing suspension ensures consistent contact between cells and stent throughout the entire surface area, improving both the sufficiency and uniformity of cell adherence. This hydraulic approach enhances manufacturing precision in terms of cell coverage uniformity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This method promotes widespread cell adherence on the stent, enhancing its endothelialization ability and reducing the likelihood of restenosis and reocclusion.
Implementation Method 1
supplying a suspension of the cells of interest into the outer cylinder, culturing the cells of interest by operating the outer cylinder and the holder such that the suspension flows to the intravascular indwelling device while being in contact with the intravascular indwelling device
Implementation Method 2
causing the outer cylinder and the holder to rotate around an axis parallel to a central axis of the outer cylinder when the suspension flows
Data Source
AI summary
A method of manufacturing an intravascular indwelling device uses a cylindrical holder (1) holding the intravascular indwelling device (20) in an internal space, and an outer cylinder (2) having an inner diameter larger than an outer diameter of the holder (1). The holder (1) holding the intravascular indwelling device (20) is accommodated in the outer cylinder (2), and a suspension(S) of cells of interest are supplied into the outer cylinder (2). The cells of interest are cultured by operating the outer cylinder (2) and the holder (1) such that the suspension(S) flows to the intravascular indwelling device (20) while being in contact with the intravascular indwelling device (20).