Stent Graft External Scaffold Tissue Integration

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Solution Overview

Problem

Conventional stent-grafts are hydrophobic, preventing tissue integration and leading to susceptibility to endoleaks and migration due to their hostile environment for cell recruitment and proliferation.

Innovation Solution

A scaffolded stent-graft with a mesh scaffold attached to the graft material's outer surface, designed to promote tissue ingrowth and integration, enhancing biological fixation and reducing the risk of endoleaks and migration.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional hydrophobic graft material is used, then the graft material provides structural integrity and barrier function, but tissue integration is prevented leading to susceptibility to endoleaks and migration

Engineering Contradiction:
Improvebiological fixationVSAvoidhydrophobicity preventing tissue integration
Core Design Contradiction:
ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent applies porous materials by incorporating a scaffold with interconnected pores into the graft structure. This scaffold provides a porous framework that allows tissue infiltration and integration, directly counteracting the hydrophobicity of the graft material. The porous structure enables cell migration and tissue growth while maintaining the structural integrity of the graft, thereby resolving the contradiction between structural function and tissue integration capability.

Inventive Principle:
Principle #31Porous materials

Solution Approach 2:

The patent employs composite materials by combining the hydrophobic graft material with a hydrophilic scaffold structure. This composite construction integrates two materials with complementary properties: the graft material provides structural integrity and barrier function, while the scaffold provides tissue integration capability. The composite structure synergistically combines these functions to eliminate the harmful effects of hydrophobicity while preserving structural requirements.

Inventive Principle:
Principle #40Composite materials

2Reliability

If tissue integration is promoted through scaffold addition, then biological fixation is enhanced, but device complexity increases

Engineering Contradiction:
Improvebiological fixationVSAvoidscaffold structure integration
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The patent applies merging by integrating the scaffold structure directly with the graft material through mechanical interlocking and chemical bonding. Rather than treating them as separate components requiring complex assembly, the scaffold and graft are combined into a unified structure where the scaffold is embedded within or attached to the graft material. This merging approach reduces device complexity by eliminating separate assembly steps while maintaining the tissue integration benefits.

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The patent applies self-service through the self-organizing properties of the scaffold structure that automatically facilitates tissue integration upon implantation. The scaffold's porous architecture inherently guides tissue growth and infiltration without requiring additional active components or complex control mechanisms. The structure serves its own function of promoting biological fixation through its passive geometric configuration, thereby avoiding increased device complexity.

Inventive Principle:
Principle #25Self-service

Data Source

PatentEP3413837B1Stent graft with external scaffolding
Publication Date: 2023.08.30 MEDTRONIC VASCULAR INC
  • EP3413837B1 patent drawingFigure 1~3B
  • EP3413837B1 patent drawingFigure 4
  • EP3413837B1 patent drawingFigure 5~6

AI summary

A scaffolded stent-graft includes a graft material comprising an inner surface and an outer surface. The inner surface defines a lumen within the graft material. The scaffolded stent-graft further includes a scaffold comprising a mesh coupled to the graft material at the outer surface. The scaffold is configured to promote tissue ingrowth therein. In this manner, the scaffold enhances tissue integration into the scaffolded stent-graft. The tissue integration enhances biological fixation of the scaffolded stent-graft in vessels minimizing the possibility of endoleaks and migration.