Sterile Connector Systems with Angled Membranes for Large-Bore Tubing
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Solution Overview
Problem
Current connector systems for forming sterile fluid connections are not scalable for large diameter tubing used in biotechnology and pharmaceutical industries, and they can damage cells or microorganisms due to undesirable shear forces, especially when transporting fluids through sharp angles.
Innovation Solution
A connector system with a large diameter passage, angled distal end face, and radiant energy-meltable membranes that form a sterile connection by melting together, allowing for the use of flexible or rigid tubing and containers, and minimizing stress on the connection.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If small diameter connectors with opaque membranes are used for sterile connections, then sterile fluid connection can be formed outside sterile environment, but the connectors are not scalable for large diameter tubing and create undesirable shear forces
Solution Approach 1:
The patent changes the key parameter of connector diameter from small to large, scaling up the connector system while maintaining the fundamental sterile connection mechanism. The large diameter passage allows the connector to be compatible with large bore tubing used in biotechnology and pharmaceutical industries, resolving the scalability issue while preserving sterile connection capabilities
Solution Approach 2:
The patent employs curved or angled distal end faces instead of sharp right angles. This curvature design allows fluid to flow through the connector without encountering sharp directional changes, thereby eliminating undesirable shear forces that could damage cells or microorganisms while maintaining the sterile connection function
2Device complexity
If sharp right angle connections are used in connectors, then connection structure is simple, but undesirable shear forces are created that can damage cells or microorganisms
Solution Approach 1:
The patent replaces sharp right angle connections with curved or angled distal end faces. This geometric modification creates smooth fluid pathways that eliminate sharp directional changes, thereby removing the source of undesirable shear forces while maintaining relatively simple connector construction
Solution Approach 2:
The patent applies different geometric qualities to different parts of the connector. The distal end face is specifically designed with curved or angled geometry to minimize shear forces, while other parts of the connector maintain simpler structures. This localized optimization addresses the harmful effect without unnecessarily complicating the entire device
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables efficient and sterile fluid connections for large-scale flow without damaging cells or microorganisms, providing a scalable and stress-reduced connection method for biotechnology and pharmaceutical applications.
Implementation Method 1
A radiant energy source is then applied to the connectors which melts the membranes so as to enable fluid communication between the connectors
Data Source
AI summary
A system for forming a fluid connection includes a first connector and a second connector. Both connectors include a tubular body having a membrane mounted on a distal end thereof. A support member facilitates the coupling of the connectors together so that the membranes are abutted together. Radiant energy is applied to the abutted membranes so as to first sterilize the membranes and then melt the membranes so that a passage is formed therethrough.