Steviol Glycoside Solubility Enhancers for Room-Temperature Dissolution

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Solution Overview

Problem

Rebaudiosides, commonly used as sweeteners, face challenges due to low water solubility, requiring high processing temperatures and labor-intensive methods to achieve dissolution, which limits their use in food and beverage applications.

Innovation Solution

The use of steviol glycoside solubility enhancers, such as hydroxycinnamic acids and phenolic compounds, to improve the solubility of rebaudiosides in aqueous solutions, allowing for higher concentrations of steviol glycosides to remain in solution at room temperature.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Temperature

If rebaudiosides are used as sweeteners, then sweetness is provided, but water solubility is low requiring high processing temperatures

Engineering Contradiction:
Improveprocessing temperatureVSAvoidwater solubility
Core Design Contradiction:
TemperatureVSQuantity of substance

Solution Approach 1:

The patent employs solubility enhancers (such as cyclodextrins, surfactants, or co-solvents) as intermediary substances that facilitate the dissolution of rebaudiosides in water. These enhancers form inclusion complexes or micellar structures that increase the apparent solubility of the poorly soluble steviol glycosides, thereby resolving the contradiction between maintaining low processing temperatures and achieving adequate solubility.

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent modifies physical-chemical parameters of the system by adjusting pH, ionic strength, or adding specific additives to change the solubility characteristics of rebaudiosides. By altering these parameters, the patent enables dissolution at lower temperatures while maintaining or enhancing the sweetness functionality.

Inventive Principle:
Principle #35Parameter changes

2Quantity of substance

If high processing temperatures are used to achieve dissolution, then solubility is improved, but processing complexity and energy consumption increase

Engineering Contradiction:
ImprovesolubilityVSAvoidenergy consumption
Core Design Contradiction:
Quantity of substanceVSUse of energy by stationary object

Solution Approach 1:

By introducing solubility enhancers as mediators, the patent eliminates the need for high-temperature processing. These enhancers enable dissolution at ambient or refrigerated temperatures, dramatically reducing energy consumption while achieving the required solubility levels for commercial applications.

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent changes the chemical environment through pH adjustment or additive incorporation, allowing dissolution to occur at lower temperatures. This parameter modification approach replaces thermal energy input with chemical facilitation, reducing overall energy consumption of the processing system.

Inventive Principle:
Principle #35Parameter changes

3Quantity of substance

If high processing temperatures are used, then dissolution is achieved, but processing time and labor intensity increase

Engineering Contradiction:
ImprovedissolutionVSAvoidprocessing time
Core Design Contradiction:
Quantity of substanceVSLoss of time

Solution Approach 1:

The patent applies solubility enhancers beforehand to pre-condition the dissolution environment. This preliminary action creates a favorable chemical environment that accelerates dissolution kinetics, allowing rapid mixing at low temperatures and significantly reducing both processing time and labor intensity compared to traditional high-temperature methods.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

Solubility enhancers act as intermediaries that bridge the gap between rebaudiosides and water, enabling rapid dissolution through enhanced wetting and solvation. This intermediary mechanism eliminates the need for prolonged heating and stirring, reducing processing time while maintaining complete dissolution.

Inventive Principle:
Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enhances the solubility of steviol glycosides like rebaudioside M and D by 1 to 100 times, enabling their effective use in food, beverages, and other sweetened compositions without the need for high-temperature processing.

Implementation Method 1

The use of steviol glycoside solubility enhancers, such as hydroxycinnamic acids and phenolic compounds, to improve the solubility of rebaudiosides in aqueous solutions

Methodology Applied
Scientific EffectSolubility enhancement: Solvation

Data Source

PatentUS12458049B2Steviol glycoside solubility enhancers
Publication Date: 2025.11.04 CARGILL INC
  • US12458049B2 patent drawing
  • US12458049B2 patent drawing
  • US12458049B2 patent drawing

AI summary

A solubilized steviol glycoside composition including one or more steviol glycosides and one or more steviol glycoside solubility enhancers can be used as a sweetener composition to sweeten other compositions (sweetenable compositions) such as foods, beverages, medicines, oral hygiene compositions, pharmaceuticals, nutraceuticals, and the like.