Stevioside M Crystal Form A Preparation and Properties
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current methods for producing stevioside M are costly, involve harsh reaction conditions, and struggle to achieve high-purity crystal forms with good water solubility, stability, and taste.
Innovation Solution
A novel crystal form A of stevioside M is developed, characterized by distinct X-ray powder diffraction peaks and a preparation method involving mixed crystallization techniques such as suspension, solution evaporation, or cooling methods.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If conventional purification methods are used for stevioside M, then production cost is reduced, but water solubility and purity are insufficient
Solution Approach 1:
The patent changes the physical and chemical parameters of the crystallization process, including using specific solvent systems (water-acetone, water-ethanol, water-isopropanol), controlling temperature ranges (4-30°C for cooling crystallization), and adjusting pH values (3-7) to obtain crystal form A with superior solubility and purity characteristics
Solution Approach 2:
The patent employs phase transition through crystallization from different solvent systems and temperature conditions to transform stevioside M into crystal form A, which exhibits enhanced water solubility (0.3-0.5% at 25°C) and stability compared to conventional forms
2Manufacturing precision
If enzyme conversion or synthesis processes are used to produce stevioside M, then purity is improved, but production cost increases and reaction conditions become harsh
Solution Approach 1:
The patent extracts and isolates crystal form A from stevioside M through selective crystallization processes using water-acetone, water-ethanol, or water-isopropanol systems, achieving high purity (95-99%) without requiring costly enzyme conversion or synthesis reactions
Solution Approach 2:
The patent uses inexpensive, readily available solvents (water, acetone, ethanol, isopropanol) for crystallization instead of expensive enzyme catalysts or complex synthesis reagents, making the process economically viable while achieving high purity
3Quantity of substance
If amorphous composition of stevioside M and stevioside D is used, then water solubility is improved, but stability deteriorates
Solution Approach 1:
The patent induces phase transition from amorphous to crystalline state by controlling crystallization conditions (temperature, solvent composition, pH), producing crystal form A that maintains high water solubility (0.3-0.5% at 25°C) while achieving superior chemical and physical stability
Solution Approach 2:
The patent creates a composite crystalline structure in crystal form A where the molecular arrangement in the crystal lattice simultaneously provides both high solubility and enhanced stability, eliminating the trade-off present in amorphous compositions
4Stability of the object's composition
If crystal forms with high crystallinity are obtained, then stability is improved, but water solubility deteriorates
Solution Approach 1:
The patent optimizes crystallization parameters including solvent selection (water-acetone, water-ethanol, water-isopropanol), temperature (4-30°C), and pH (3-7) to produce crystal form A with a unique lattice structure that achieves both high crystallinity (superior stability) and high water solubility (0.3-0.5% at 25°C)
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The novel crystal form A of stevioside M exhibits high crystallinity, low hygroscopicity, high stability, and improved water solubility, making it suitable for use in food, healthcare, and pharmaceutical applications.
Implementation Method 1
In an X-ray powder diffraction method using Cu-Kα, the crystal form A has distinct characteristic diffraction peaks at about 4.30, 6.57, 8.04, 16.31, 17.57 and 20.91, with the 2θ angles expressed in degrees
Implementation Method 2
A novel crystal form A of stevioside M is developed, characterized by distinct X-ray powder diffraction peaks and a preparation method involving mixed crystallization techniques such as suspension, solution evaporation, or cooling methods
Data Source
Figure 1~2
Figure 3~4
Figure 5~6
AI summary
The present invention relates to a stevioside M crystal form, a preparation method therefor and a use thereof, and specifically, relates to a naturally extracted high-intensity sweetener, i.e., a stevioside M crystal form A, the preparation method therefor and the user thereof. By means of comprehensive characterization of the new crystal form, the new crystal form is found to have advantages such as a high degree of crystallinity, good stability, and low hygroscopicity, and is applicable to a more comprehensive field of application. The preparation method in the present invention is simple and easy to operate, has high selectivity and good reproducibility, and can stably obtain the target crystal form.