Stilbene Purification via Cyclodextrin Inclusion Complexation
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current methods for producing purified stilbene compounds are inefficient and lack convenience, as they often require complex processing steps such as enzyme addition, adsorption, and filtration.
Innovation Solution
The addition of γ-cyclodextrin (γ-CD) to a liquid containing a stilbene compound results in a precipitate that can be separated, allowing for the purification of the stilbene compound through a simpler method involving centrifugation and filtration, with the option to further purify using organic solvents like ethanol.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If conventional purification methods (enzyme addition, adsorption, filtration) are used, then stilbene compounds can be purified from plant extracts, but the process becomes complex and inefficient
Solution Approach 1:
The invention extracts and utilizes the natural inclusion complexation ability of cyclodextrin to selectively bind with stilbene compounds from plant extracts. By adding cyclodextrin to the extract, the stilbene compound is selectively extracted into the cyclodextrin inclusion complex, which then precipitates out. This simple extraction-precipitation process replaces the complex multi-step conventional purification methods while achieving effective purification of stilbene compounds.
2Manufacturing precision
If conventional purification methods are used, then stilbene compounds can be purified, but the process requires multiple steps including enzyme addition, adsorption, and filtration
Solution Approach 1:
The invention merges multiple purification functions into a single operation. By adding cyclodextrin to the plant extract, the process simultaneously achieves extraction of stilbene compounds, separation from other plant components, and concentration in one step. The cyclodextrin inclusion complex formation and precipitation combine these functions, eliminating the need for separate enzyme treatment, adsorption, and filtration steps required by conventional methods.
3Reliability
If cyclodextrin inclusion complexation is used to improve solubility and absorption, then polyphenol properties are enhanced, but additional purification steps are needed to remove cyclodextrin
Solution Approach 1:
Instead of using cyclodextrin to improve solubility and then needing to remove it (the conventional approach), the invention inverts the logic: cyclodextrin is used to precipitate and concentrate the stilbene compound, and the cyclodextrin-stilbene complex itself becomes the final product. This inversion eliminates the need for additional purification steps to remove cyclodextrin, as the inclusion complex is the desired deliverable that provides both purification and enhanced solubility/absorption properties.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This method effectively increases the purity of stilbene compounds, such as piceatannol, from plant extracts, achieving a higher purity level with a more straightforward process compared to existing methods.
Implementation Method 1
the addition of γ-cyclodextrin (γ-CD) to a liquid containing a stilbene compound results in a precipitate containing γ-CD and the stilbene compound
Implementation Method 2
The precipitate may have been separated from the liquid
Implementation Method 3
separating the obtained precipitate
Data Source
AI summary
The present invention is directed to provide a precipitate obtained by adding γ-cyclodextrin to a liquid containing a stilbene compound. The precipitate according to the present invention is used as the precipitate obtained by adding γ-cyclodextrin to the liquid containing a stilbene compound.