Stirring Separation for Plectranthus amboinicus Extracts

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Solution Overview

Problem

Conventional separation processes for extracting active ingredients from Plectranthus amboinicus are time-consuming and difficult to control, especially for large-scale production, and do not yield effective extracts for treating skin disorders.

Innovation Solution

A stirring separation method using an absorbing resin like DIAION, with differential solvent extraction steps, replaces traditional column chromatographic separation, allowing for faster and more effective production of Plectranthus amboinicus extracts.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If conventional column chromatographic separation is used, then separation of active ingredients is achieved, but the process is time-consuming and difficult to control for large-scale production

Engineering Contradiction:

Improvethroughput of extraction processVSAvoidtime required for separation process

Core Design Contradiction:

ProductivityVSLoss of time

Solution Approach 1:

The patent extracts the active ingredients from the plant material using solvent extraction, then separates them from the solvent and plant debris through filtration and centrifugation. This extraction approach enables scalable production while maintaining separation effectiveness, resolving the contradiction between throughput and time consumption.

Inventive Principle:

Principle #2Taking out (Extraction)

Solution Approach 2:

The patent replaces the mechanical column chromatographic separation system with a combination of solvent extraction followed by filtration and centrifugation. This substitution simplifies the mechanical complexity of the separation process while improving controllability and scalability for large-scale production, thereby increasing productivity without excessive time loss.

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

2Reliability

If conventional separation processes are used, then active ingredients are separated, but the extracts are not effective for treating skin disorders

Engineering Contradiction:

Improveeffectiveness of extract for treating skin disordersVSAvoidcomplexity of separation process

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent optimizes extraction parameters including solvent composition (ethanol-water mixtures at specific ratios), extraction temperature, and contact time to maximize the yield of bioactive compounds with proven skin healing properties. This parameter optimization ensures the extracts are therapeutically effective while using a relatively simple extraction-process rather than complex multi-step separation.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent uses specific solvents as intermediaries to selectively extract bioactive compounds from the plant material. The solvent system acts as a mediator that preferentially dissolves and transports the therapeutic compounds, ensuring extract effectiveness while keeping the overall process simpler than direct complex separation methods.

Inventive Principle:

Principle #24Intermediary (Mediator)

3Ease of manufacture

If traditional column chromatographic separation is used, then separation is achieved, but it is difficult to control for mass production

Engineering Contradiction:

Improvecontrollability of separation processVSAvoidscalability to large-scale production

Core Design Contradiction:

Ease of manufactureVSProductivity

Solution Approach 1:

The patent segments the extraction and separation process into distinct, independently controllable stages: extraction with optimized solvent systems, filtration to remove plant debris, and centrifugation for final clarification. This segmentation allows each stage to be optimized and controlled separately, facilitating scalable mass production while maintaining ease of manufacture.

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The patent performs preliminary optimization of extraction parameters (solvent composition, temperature, time) before scaling up to mass production. This preliminary action establishes controlled conditions that can be replicated and maintained at larger scales, making the process easier to manufacture and control while enabling high productivity.

Inventive Principle:

Principle #10Preliminary action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The stirring separation method significantly increases throughput, producing more effective Plectranthus amboinicus extracts that enhance wound healing in diabetic patients, outperforming traditional column chromatographic separation methods.

Implementation Method 1

contacting the dried Plectranthus amboinicus leaves with a leaf extracting solvent to obtain a Plectranthus amboinicus crude extract; concentrating the Plectranthus amboinicus crude extract; and treating the concentrated Plectranthus amboinicus crude extract by utilizing a stirring separation method to obtain a Plectranthus amboinicus extract

Methodology Applied

Scientific EffectAdsorption: Adsorption

Data Source

PatentUS9872879B2Process for the preparation of plant extracts for treating skin disorders and enhancing healing of wounds

Publication Date: 2018.01.23 DEV CENT FOR BIOTECHNOLOGY

AI summary

The present invention provides a process for the preparation of Plectranthus amboinicus extracts using a stirring separation method. The present invention also relates to a pharmaceutical composition comprising the Plectranthus amboinicus crude extract and/or extract for treating skin disorders, including enhancing the healing of wounds, especially in diabetic patients.