Streptococcus Skin Composition for Atopic Dermatitis Relief

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Solution Overview

Problem

Current treatments for inflammatory skin diseases such as atopic dermatitis, contact dermatitis, and seborrheic dermatitis, including antihistamines and corticosteroids, provide temporary relief with severe side effects, highlighting the need for more effective and safer alternatives.

Innovation Solution

A cosmetic and pharmaceutical composition incorporating Streptococcus spp. strains, cultures, lysates, extracts, or fermentation products, or the core efficacy substance Cyclo(Gly-Pro), which synergistically improve skin barrier function, reduce inflammation, and alleviate symptoms like itchiness.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional medications such as antihistamines and corticosteroids are used to treat inflammatory skin diseases, then temporary relief of symptoms is achieved, but severe side effects occur

Engineering Contradiction:

Improvesymptom relief effectivenessVSAvoidside effects

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent uses probiotic bacteria (Lactobacillus rhamnosus, Bifidobacterium animalis, Streptococcus thermophilus) and their fermentation products as intermediary substances to modulate the skin microbiome and immune response. These probiotics act as mediators between the external environment and the host immune system, providing anti-inflammatory effects without the harmful side effects of conventional medications like corticosteroids and antihistamines

Inventive Principle:

Principle #24Intermediary (Mediator)

2Reliability

If the skin microbiome is disrupted by conventional treatments, then inflammatory symptoms are suppressed temporarily, but the underlying cause of skin disease is not addressed

Engineering Contradiction:

Improveinflammation suppressionVSAvoidskin microbiome balance

Core Design Contradiction:

ReliabilityVSStability of the object's composition

Solution Approach 1:

The patent employs probiotic bacteria that can self-replicate and colonize the skin, providing continuous anti-inflammatory effects. The probiotics serve themselves by utilizing available nutrients in the skin environment, while simultaneously producing beneficial effects such as competing with pathogenic bacteria, modulating immune responses, and maintaining skin barrier function without requiring continuous external application of medications

Inventive Principle:

Principle #25Self-service

3Reliability

If strong anti-inflammatory medications are applied to reduce inflammatory markers, then acute symptoms are relieved, but long-term skin health is compromised

Engineering Contradiction:

Improveacute symptom reliefVSAvoidlong-term skin health

Core Design Contradiction:

ReliabilityVSDuration of action of stationary object

Solution Approach 1:

The patent applies probiotics and their fermentation products in advance to prevent the development of inflammatory skin diseases and to maintain long-term skin health. By establishing a balanced microbiome early, the probiotics prevent the need for strong anti-inflammatory medications later, thereby avoiding long-term side effects while providing sustained protection against skin diseases

Inventive Principle:

Principle #10Preliminary action

Data Source

PatentEP4656179A1Composition containing streptococcus sp. strain for prevention, alleviation, or treatment of skin diseases

Publication Date: 2025.12.03 COSMAX INC

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AI summary

The present invention provides a composition for the prevention, alleviation, or treatment of skin disease, comprising three Streptococcus spp. strains, cultures, lysates, extracts, or fermentation products thereof, or a core efficacy substance thereof, Cyclo(Gly-Pro). The composition may be advantageously utilized for the prevention, alleviation, or treatment of atopic dermatitis, or the like.