Streptolysin O Bronchodilation in COPD Treatment

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Solution Overview

Problem

Current therapies for bronchoconstriction and asthma lack effective long-acting bronchodilation and prevention of bronchospasm, with existing bronchodilators providing either short-term relief or significant side effects.

Innovation Solution

Administration of streptolysin O (SLO) and biologically active fragments, preferably in a sublingual liquid form, to promote long-acting bronchodilation and prevent bronchospasm, potentially combined with DNA, in a dosage ranging from 0.0032 to 50 units per day.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Duration of action of moving object

If existing bronchodilators are administered, then short-term relief of bronchoconstriction is achieved, but long-acting bronchodilation and prevention of bronchospasm are insufficient

Engineering Contradiction:

Improveduration of bronchodilationVSAvoideffectiveness of bronchodilation

Core Design Contradiction:

Duration of action of moving objectVSReliability

Solution Approach 1:

The patent changes the chemical parameter of the bronchodilator agent by using streptolysin O instead of conventional bronchodilators. This parameter change results in both long-acting bronchodilation and effective prevention of bronchospasm, resolving the contradiction between duration and reliability of treatment.

Inventive Principle:

Principle #35Parameter changes

2Reliability

If conventional bronchodilators are used, then bronchoconstriction relief is provided, but significant side effects occur

Engineering Contradiction:

Improveeffectiveness of bronchoconstriction reliefVSAvoidside effects

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent utilizes streptolysin O, a substance that is normally a bacterial toxin, and converts its harmful properties into a beneficial therapeutic agent. The streptolysin O provides effective bronchoconstriction relief without the significant side effects associated with conventional bronchodilators, thus converting a harmful substance into a beneficial treatment.

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

3Duration of action of moving object

If streptolysin O is administered, then long-acting bronchodilation and bronchospasm prevention are achieved, but the mechanism of action needs to be elucidated

Engineering Contradiction:

Improveduration of bronchodilationVSAvoidmechanism of action

Core Design Contradiction:

Duration of action of moving objectVSDifficulty of detecting and measuring

Solution Approach 1:

The patent employs pulmonary function tests to measure and monitor the effects of streptolysin O administration. This feedback mechanism allows for the detection and measurement of bronchodilation effects, helping to elucidate the mechanism of action while confirming the long-acting bronchodilation and bronchospasm prevention benefits.

Inventive Principle:

Principle #23Feedback

Data Source

PatentUS8980826B2Method of treating chronic obstructive pulmonary disease

Publication Date: 2015.03.17 BEECH TREE LABS

AI summary

The present invention relates to a method of promoting bronchodilation by administration of streptolysin O to a subject in need thereof.