Strip Detector Protruding Tip for Pain-Free Tear Sampling
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Solution Overview
Problem
Direct collection of liquid samples from living organisms using existing detectors can cause pain and burden on the organism, and often results in low sensitivity and insufficient sample amounts, making it difficult to obtain reliable detection results.
Innovation Solution
A strip-shaped detector with a protruding collecting member that minimizes contact with the organism, a holding member with a labeling reagent, a detecting member for capturing analyte complexes, and an absorbing member, all arranged on a liquid-impermeable supporting member to facilitate capillary flow and reduce sample leakage, using a fibrous substrate like wood pulp for enhanced sensitivity and comfort.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If the detector contacts the living organism for direct sample collection, then the sample collection is simplified, but the living organism feels pain and suffers health damage
Solution Approach 1:
The detector is divided into multiple functional members (collecting member, holding member, detecting member, absorbing member) arranged in sequence. The collecting member with protruding portion is separated from the supporting member, allowing only the necessary part to contact the organism while other parts remain isolated, thus simplifying sample collection while reducing harm to the organism.
2Quantity of substance
If the contact time between detector and living organism is extended to collect large amount of liquid sample, then sufficient sample amount is obtained, but the burden on the living organism increases
Solution Approach 1:
The collecting member has a protruding portion with specific local characteristics (flat surface, extended length) that enhance sample collection efficiency. This localized optimization allows sufficient sample collection in shorter time without increasing overall contact duration, thus obtaining adequate sample amount while reducing burden on the organism.
3Duration of action of moving object
If the contact time between detector and living organism is shortened to reduce burden, then the organism burden is reduced, but sufficient liquid sample amount cannot be obtained
Solution Approach 1:
The collecting member is pre-configured with a protruding portion that optimizes contact with the sample source. This preliminary structural preparation enables efficient sample uptake during brief contact periods, allowing sufficient sample collection without extending contact time, thus reducing organism burden while obtaining adequate sample volume.
4Object-affected harmful factors
If the collecting member is made to protrude from the supporting member, then contact area with organism is reduced, but device complexity increases
Solution Approach 1:
The collecting member, holding member, detecting member, and absorbing member are integrated onto a single supporting member structure. The protruding portion of the collecting member is formed as part of this integrated assembly, reducing contact area with the organism while avoiding the complexity of separate components. The merging of functions into a unified strip-shaped detector simplifies the overall device structure.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The detector allows for efficient and pain-reduced collection of small liquid samples, improving detection sensitivity and reducing the burden on the organism while ensuring sufficient detection results, suitable for use in chromatography applications such as tear collection from humans.
Implementation Method 1
the liquid sample moves through the inside of these members in the above order of the members by capillarity
Data Source
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AI summary
Provided is a strip-shaped detector that detects an analyte in a liquid sample. The detector includes a collecting member that directly collects a liquid sample from a living organism, a holding member that holds a labeling reagent binding specifically to the analyte in a state where the labeling reagent can move along with the movement of the liquid sample, a detecting member to which a detection reagent is immobilized which captures a complex of the analyte and the labeling reagent by binding specifically to the analyte, an absorbing member that can absorb the liquid sample, and a liquid-impermeable supporting member, wherein the respective members are arranged on the supporting member in the longitudinal direction of the detector so that the liquid sample moves through the inside of these members, and the collecting member includes a protruding portion sticking out of the supporting member at the upstream side in the movement direction of the liquid sample.