Stromal Stem Cell Therapeutics for Wound and Liver Repair
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Chronic diseases such as inflammatory liver diseases and non-healing wounds often require extensive surgery or amputation, with current treatments failing to effectively manage symptoms and prevent morbidity and mortality.
Innovation Solution
Topical application of a composition containing stromal stem cells, often suspended in a collagen matrix, to wounds, and intravenous administration of stromal stem cells for liver diseases, with the stem cells being at least 30% SDC2+ and administered in specific doses based on body weight, to ameliorate symptoms.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If standard treatment is used for chronic diseases, then morbidity and mortality are prevented or delayed, but extensive surgery or amputation is required
Solution Approach 1:
The patent uses stromal stem cells as an intermediary therapeutic agent to mediate between the patient's chronic condition and the desired healing outcome. These stem cells are administered topically or systemically to promote tissue regeneration and reduce inflammation, thereby preventing the need for extensive surgical intervention while maintaining disease control
Solution Approach 2:
The patent changes the therapeutic parameter from conventional surgical intervention to biological regeneration through stem cell therapy. By altering the treatment approach from mechanical removal (surgery/amputation) to biological repair (stem cell-mediated regeneration), the patent achieves disease management without the need for extensive procedures
2Reliability
If stromal stem cells are administered in high doses, then wound healing and liver function improve significantly, but treatment cost and complexity increase
Solution Approach 1:
The patent optimizes the dosage parameter of stromal stem cells by establishing specific concentration ranges (at least 10³ to 10⁷ cells) and administration frequencies. This parameter optimization achieves effective therapeutic outcomes while avoiding unnecessarily high doses that would increase cost and complexity without additional benefit
Data Source
AI summary
Provided herein are stromal stem cell therapeutics and methods of use in treating disease.