Strontium-Ion Implant Surface for Rapid Osseointegration
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Solution Overview
Problem
Current bone implant technologies face challenges in achieving rapid and strong osseointegration, which is essential for immediate or early loading of implants, as existing methods may not provide sufficient stability and bond strength between the implant and bone tissue.
Innovation Solution
A biocompatible implant with a surface oxide layer comprising homogenously dispersed strontium ions, which enhances bone formation by increasing alkaline phosphatase production, osteoprotegerin, and prostaglandin E2, leading to improved osseointegration and mechanical bond strength.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Loss of time
If immediate or early loading is performed, then treatment time is reduced and patient comfort is improved, but implant stability and bond strength may be insufficient
Solution Approach 1:
The implant surface is pre-treated with strontium ions before implantation to stimulate accelerated bone formation. This preliminary chemical modification of the surface enables faster osseointegration, allowing the implant to achieve sufficient stability in a shorter time frame for immediate or early loading protocols.
Solution Approach 2:
The chemical composition of the implant surface is modified by incorporating strontium ions, which changes the biological response parameters. This parameter change accelerates bone formation rates and enhances bone-implant bonding strength, enabling reduced healing periods while maintaining reliability.
2Productivity
If conventional implant surfaces are used, then manufacturing is simpler, but osseointegration rate is slower
Solution Approach 1:
The surface chemistry parameters are modified by introducing strontium ions through ion implantation or chemical treatment. This changes the biological activity of the surface, accelerating osseointegration rates while using established surface modification techniques that remain relatively simple to manufacture.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The strontium-ion treated implant surface promotes increased bone formation and attachment, allowing for improved stability and faster integration of the implant into bone tissue, as demonstrated by higher removal torque values and enhanced bone tissue response.
Implementation Method 1
said oxide layer has a thickness within the range of from 2 to 100 nm and comprises homogenously dispersed strontium ions
Data Source
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AI summary
The present invention is based on that local administration of strontium ions in bone tissue has been found to improve the bone formation and bone mass upon implantation of a bone tissue implant in said bone tissue. In particular, the invention relates to a bone tissue implant having an implant surface covered by an oxide layer comprising strontium ions and a method for the manufacture thereof. A blasting powder comprising strontium ions, a method for locally increasing bone formation, and the use of strontium ions or a salt thereof for manufacturing a pharmaceutical composition for locally increasing bone formation are also provided by the present invention.