Strontium Silicate Cement Paste for Fast-Setting Bone Defect Filling
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Solution Overview
Problem
Existing pre-mixed calcium silicate-based dental filling materials suffer from long setting times, inadequate strength, and complex surgical procedures, while calcium phosphate cements lack sufficient compressive strength and are prone to breakage.
Innovation Solution
A pre-mixed strontium silicate-based cement paste composition comprising strontium silicate, a non-aqueous solvent, and optional radiopaque and calcium phosphate compounds, which is mixed and injected as a stable fluid, hydrating and hardening upon contact with physiological fluids, offering fast setting and improved biocompatibility.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional hydraulic cements (Portland cement, calcium silicate cement, calcium aluminate cement) are used for bone defect filling, then the defects can be filled and consolidated, but the cements cause inflammatory responses, foreign body reactions, and lack of bioactivity leading to poor integration with host bone
Solution Approach 1:
The patent changes the chemical composition parameters of the hydraulic cement from conventional calcium-based cements to a strontium silicate-based system. Specifically, it uses strontium silicate powder (SrSiO3) as the main ingredient combined with specific ratios of calcium oxide (CaO), silica (SiO2), and water, creating a cement that undergoes different chemical reactions (forming strontium hydroxide and calcium silicate hydrate) that eliminate harmful inflammatory responses while maintaining filling and consolidation functions.
Solution Approach 2:
The patent creates a composite hydraulic cement system by combining strontium silicate powder with calcium oxide, silica, and water in specific proportions. This composite formulation allows the material to exhibit both the mechanical properties needed for bone defect filling and the bioactive properties that promote bone integration, while the strontium silicate component specifically provides anti-inflammatory effects.
2Reliability
If pre-mixed strontium silicate-based hydraulic cement is prepared with optimal composition, then bioactivity and bone integration are improved, but the preparation process becomes more complex requiring precise control of multiple ingredients and parameters
Solution Approach 1:
The patent applies preliminary action by pre-mixing the strontium silicate powder with calcium oxide and silica in predetermined optimal ratios before application to the bone defect. This pre-preparation of the powder mixture ensures that when water is added during surgery, the cement achieves optimal hydration and setting characteristics immediately, eliminating the need for complex adjustments during the surgical procedure while maintaining precise compositional control.
3Productivity
If the hydraulic cement is designed to set rapidly upon contact with water, then surgical efficiency is improved, but control over the setting time and final strength may be compromised
Solution Approach 1:
The patent controls setting time and final strength by precisely adjusting the chemical parameters of the cement formulation. Specifically, it controls the ratio of strontium silicate to calcium oxide and silica,以及 the particle size distribution of the powders. These parameter adjustments ensure that upon contact with water, the cement sets rapidly enough for surgical efficiency while maintaining predictable setting time and achieving adequate final strength for bone integration.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The strontium silicate-based cement provides a fast-setting, high-strength, and biocompatible material suitable for dental and orthopedic applications, promoting bone formation and enhancing bone strength with minimal temperature rise during reaction.
Implementation Method 1
a hydraulic cementing paste composition, wherein the hydraulic cementing paste composition comprises strontium silicate powder, calcium oxide, silica and water by weight
Implementation Method 2
the hydraulic cementing paste composition comprises strontium silicate powder, calcium oxide, silica and water by weight
Data Source
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AI summary
A pre-mixed strontium silicate-based biological hydraulic cement paste composition and preparation method and use thereof are disclosed. The pre-mixed strontium silicate-based biological hydraulic cement paste of the disclosure uses strontium silicate as the main phase and at least one non-aqueous solvent that is miscible with water, and preferably, it may further include at least one calcium phosphate compound and at least one radiopaque material, to prepare a biological hydraulic cement paste with excellent injectability. The material remains as a fluid under a sealed condition, and hydrates, solidifies and hardens when it is placed in a physiological environment and contacts with a physiological body fluid. The strontium silicate-based material having excellent biocompatibility and biological activity is used to prepare a pre-mixed strontium silicate-based cement paste, which can be used for medical and dental applications including fields of pulp capping, root canal therapy, dental restorations and the like.