Breast milk structured lipid simulating the composition of triglycerides and method for preparing the same
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current infant formula compositions struggle to accurately mimic the complex triglyceride composition of breast milk lipid, failing to meet both national food safety standards and the unique digestive and metabolic needs of infants.
Innovation Solution
A method involving acidolysis reactions catalyzed by sn-1,3 lipase, lipid blending, and fractionation to produce a breast milk structured lipid with a similarity of over 90% to breast milk lipid, adjusting fatty acid composition and distribution to meet both food safety standards and breast milk lipid requirements, while minimizing harmful substances like esterified propenyl glycerol and trans fatty acids.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If OPO (1,3-diacylglycerol-2-palmitic acid triglyceride) is added to infant formula to simulate breast milk lipid composition, then the similarity in fatty acid distribution is improved, but the complexity of triglyceride composition prevents meeting both national food safety standards and breast milk lipid composition requirements simultaneously
Solution Approach 1:
The patent segments the triglyceride structure into specific positional arrangements (sn-1,3 vs sn-2) and applies different fatty acid compositions to each position. By controlling the distribution of palmitic acid primarily at sn-2 position and unsaturated fatty acids at sn-1,3 positions, the method creates a structured lipid that simultaneously achieves high similarity to breast milk composition and compliance with national standards for OPO content and trans fatty acid limits.
Solution Approach 2:
The patent applies local quality by creating non-uniform fatty acid distribution within the triglyceride molecule. Specifically, palmitic acid is concentrated at the sn-2 position while unsaturated fatty acids are placed at sn-1,3 positions. This localized arrangement replicates the complex structure of breast milk triglycerides and enables simultaneous satisfaction of multiple compositional requirements that cannot be met with uniform distribution.
2Ease of manufacture
If the triglyceride composition in infant formula is simplified for ease of production, then the manufacturing process becomes easier, but the ability to meet breast milk lipid composition requirements deteriorates
Solution Approach 1:
The patent applies parameter changes by precisely controlling the positional distribution parameters of fatty acids within triglyceride molecules. Rather than changing the overall complexity, it adjusts specific parameters such as the proportion of palmitic acid at sn-2 position (60% or more) and unsaturated fatty acids at sn-1,3 positions. These parameter adjustments enable replication of breast milk composition through standard industrial processes without requiring overly complex manufacturing steps.
3Manufacturing precision
If multiple types of triglycerides are used to replicate breast milk composition, then the composition similarity is improved, but the device and process complexity increases
Solution Approach 1:
The patent applies universality by developing a single structured lipid product (structured lipid powder) that performs multiple functions: it provides energy, supplies essential fatty acids, replicates breast milk triglyceride composition, and ensures compliance with national standards. This multi-functional approach eliminates the need for multiple separate lipid components, thereby achieving high composition accuracy while maintaining relatively simple production processes and device requirements.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method produces a breast milk structured lipid that closely resembles breast milk lipid in composition and distribution, meeting national food safety standards and addressing the unique digestive needs of infants, with controlled levels of harmful substances.
Implementation Method 1
performing the acidolysis reaction between a palm stearin catalyzed by a sn-1,3 lipase and blended fatty acids
Implementation Method 2
catalyzed by a sn-1,3 lipase
Implementation Method 3
adjusting the content of triglyceride palmitic acid in the acidolysis reaction product via fractionation and extraction
Implementation Method 4
adjusting the content of triglyceride palmitic acid in the acidolysis reaction product via fractionation and extraction
Implementation Method 5
removing the fatty acids via vacuum distillation
Data Source
AI summary
The present invention provides a breast milk structured lipid simulating the composition of triglycerides and the method for preparing the same. The breast milk structured lipid exhibits a similarity of over 90% to breast milk lipid, including the contents of less than 0.3 mg/kg of esterified propenyl glycerol, less than 0.5 mg/kg of chloropropanol esters, and less than 0.3 g/100 g of trans fatty acids. The final product of the present invention exhibits a composition highly similar to breast milk while also meeting the requirements of the national food safety standard GB30604-2015.