Sublingual Nicotine Compositions for Mucosal Absorption

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Solution Overview

Problem

Current oral nicotine delivery methods face challenges in achieving effective absorption without direct contact with the stomach and digestive organs, leading to inefficiencies and side effects.

Innovation Solution

Compositions comprising nicotine, sunflower oil, sodium bicarbonate, and carriers like microcrystalline cellulose and inulin are developed for sublingual or buccal delivery, allowing absorption through the mucosa and avoiding direct contact with the stomach, intestines.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If oral nicotine delivery is used, then nicotine can be absorbed through the digestive system, but direct contact with the stomach and digestive organs causes inefficiencies and side effects

Engineering Contradiction:

Improveabsorption efficiencyVSAvoiddirect contact with stomach and digestive organs

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent uses the buccal mucosa as an intermediary absorption pathway between the nicotine delivery system and the bloodstream. By placing nicotine-containing compositions in the buccal cavity, the mucosal tissue serves as a mediator that absorbs nicotine without requiring it to pass through the stomach and digestive organs, thus eliminating direct harmful contact while maintaining effective absorption

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent replaces the mechanical digestion pathway (stomach and intestines) with a biological absorption pathway (buccal mucosa). Instead of relying on mechanical breakdown and chemical digestion, the system uses the permeable mucosal tissue to directly absorb nicotine molecules into the bloodstream, substituting a more efficient and less harmful absorption mechanism

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

2Productivity

If traditional oral nicotine delivery methods are used, then nicotine can be delivered to the digestive system, but absorption is inefficient and side effects occur

Engineering Contradiction:

Improvenicotine delivery efficacyVSAvoidabsorption efficiency

Core Design Contradiction:

ProductivityVSReliability

Solution Approach 1:

The patent changes the delivery parameter from gastrointestinal route to buccal route. By altering the administration pathway parameter, the system achieves more reliable and efficient absorption. The buccal route provides direct access to the sublingual area with high vascularity, improving nicotine delivery efficacy while eliminating the inefficiencies and side effects of digestive system contact

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The compositions enhance nicotine plasma levels and absorption efficiency, as demonstrated by increased plasma concentrations and prolonged release profiles in animal studies, improving delivery efficacy compared to traditional methods.

Implementation Method 1

allowing absorption through the mucosa and avoiding direct contact with the stomach, intestines

Methodology Applied

Scientific EffectMucosal absorption: Absorption (physical)

Data Source

PatentUS11700875B1Compositions and methods for sublingual delivery of nicotine

Publication Date: 2023.07.18 POVIVA CORP

AI summary

Disclosed herein are compositions and methods for oral delivery of nicotine and nicotine derivatives. In one embodiment the nicotine is delivered in an oral packets, pouches, or sachets.