Submicron Lipid Coating for Stable Active Ingredient Release
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Solution Overview
Problem
Existing coating systems fail to effectively improve the stability, sensory properties, and controlled release of active ingredients, particularly for strong-tasting fat-soluble compounds, due to inadequate particle size distribution and composition.
Innovation Solution
A coating system comprising a lipid compound with a mass median diameter (MMD) less than 1 μm, combined with film-forming compounds and plasticizers, enhances the stability and controlled release of active ingredients by optimizing particle size and composition.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional coating systems with larger lipid particles are used, then the coating can be applied, but the storage stability and controlled release of active ingredients are insufficient
Solution Approach 1:
The patent applies parameter changes by reducing the mass median diameter of lipid compounds from conventional sizes to less than 1 μm (preferably 0.1-0.9 μm). This parameter modification fundamentally improves storage stability and controlled release properties while maintaining coating applicability, directly resolving the contradiction between reliability and manufacturing precision.
2Object-affected harmful factors
If conventional coating systems are used, then the coating can be applied, but the sensory properties (smell and odour) are not improved
Solution Approach 1:
By changing the particle size parameter to MMD < 1 μm, the coating system improves sensory properties by reducing odour and improving taste characteristics of the coated composition, while maintaining proper coating application and formation.
3Duration of action of moving object
If conventional coating systems with larger particles are used, then the coating can be applied, but the controlled release of active ingredient is not achieved
Solution Approach 1:
The patent implements parameter changes by specifying mass median diameter of less than 1 μm for lipid compounds, which enables controlled release of active ingredients over extended periods while maintaining coating applicability and formulation stability.
4Reliability
If the lipid compound particle size is reduced to less than 1 μm, then storage stability and controlled release are improved, but the coating formulation complexity increases
Solution Approach 1:
While reducing particle size to MMD < 1 μm does improve reliability, the patent manages formulation complexity by providing specific composition ranges (lipid 10-30 wt%, film forming compound 55-80 wt%, plasticizer 5-25 wt%) that simplify the coating system despite the advanced particle size requirement.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The coating system significantly improves storage stability, sensory attributes, and controlled release of active ingredients, demonstrated by a reduction in water vapor permeability and enhanced performance in food, feed, dietary supplements, and pharmaceutical products.
Implementation Method 1
demonstrated by a reduction in water vapor permeability
Data Source
AI summary
The present patent application relates to a novel coating system, coated compositions with such a coating system, as well as to the use of such compositions in the production food, feed, dietary supplements and/or pharmaceutical products, as well as to food, feed, dietary supplements and/or pharmaceutical products comprising such compositions.