Substance P Wound Composition Stabilization
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current wound healing agents, such as Fucidin and Madecassol, face challenges with increasing antibiotic resistance and side effects like allergic reactions, and existing therapeutic agents using substance P (SP) face issues with stability and cytotoxicity, necessitating a composition that enhances wound healing efficacy without these drawbacks.
Innovation Solution
A pharmaceutical composition comprising a thickener, an antioxidant, and SP, specifically using hydroxyethyl cellulose as the thickener and sodium thiosulfate as the antioxidant, which stabilizes SP and improves wound healing by promoting angiogenesis, epidermal regeneration, and collagen synthesis.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If substance P is used as a wound healing agent, then wound healing efficacy is improved, but stability and cytotoxicity issues arise
Solution Approach 1:
The patent uses an antioxidant as an intermediary substance to protect substance P from oxidation and degradation. The antioxidant acts as a mediator between substance P and the external environment, preventing harmful oxidative reactions while maintaining substance P's therapeutic properties and stability in the formulation.
Solution Approach 2:
The patent optimizes the concentration parameters of substance P and antioxidant in the composition to achieve stable formulation. By carefully controlling the ratio and amount of each component, the patent maintains substance P's efficacy while preventing its degradation and cytotoxicity through parameter optimization.
2Reliability
If commercially available wound healing agents like Fucidin and Madecassol are used, then wound treatment is provided, but antibiotic resistance and side effects occur
Solution Approach 1:
The patent extracts and utilizes the active component substance P from natural sources, creating a formulation that provides wound healing benefits without the antibiotic resistance and side effect problems associated with conventional antibiotic-containing products like Fucidin. This extraction approach allows selective use of beneficial components while eliminating harmful ones.
Solution Approach 2:
The patent employs substance P in a formulation that provides effective wound healing without requiring long-term antibiotic use, thereby avoiding the development of antibiotic resistance. The composition delivers therapeutic effects in a controlled manner that prevents the emergence of resistant bacterial strains.
3Reliability
If stem cells are used as raw material for wound healing, then therapeutic effect is achieved, but cytotoxicity occurs after cell death
Solution Approach 1:
Instead of using living stem cells that may die and cause cytotoxicity, the patent uses substance P, a stable peptide that copies or mimics the beneficial therapeutic effects of stem cells. This copying approach provides similar wound healing benefits without the risks associated with live cell therapy, including cytotoxicity from cell death.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition demonstrates superior wound size reduction, angiogenic, and regenerative effects compared to commercial wound healing agents, with improved stability and reduced side effects, making it an effective treatment for wound healing.
Implementation Method 1
a pharmaceutical composition for wound healing including a thickener, an antioxidant, a surfactant, and substance P (SP)
Implementation Method 2
a pharmaceutical composition for wound healing including a thickener, an antioxidant, a surfactant, and substance P (SP)
Data Source
AI summary
Provided are a pharmaceutical composition for wound healing including a surfactant, an antioxidant, a thickener, and SP, a method of treating a wound including administering the pharmaceutical composition to a subject, and a quasi-drug composition for wound healing including a surfactant, an antioxidant, a thickener, and substance.The pharmaceutical composition of the present invention reduces a wound size, generates new blood vessels, shows dermal and epidermal regeneration effects, matures granulation tissues, and synthesizes collagen, and thus may be used for wound healing.