Substituted 2-Aminoazines for Broad-Spectrum Crop Weed Control

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

Existing herbicides for selective control of broad-leaved weeds and weed grasses in crops suffer from insufficient herbicidal activity, narrow spectrum of control, low selectivity, toxicological unfavourable profiles, economic production issues, and activity dependence on environmental conditions.

Innovation Solution

Development of substituted 2-aminoazines and their salts, which can form various tautomeric structures under different conditions, offering improved herbicidal activity, selectivity, and compatibility with crops, and are economically viable to produce.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Adaptability or versatility

If known herbicides are used for selective control of broad-leaved weeds and weed grasses, then herbicidal activity is achieved, but the spectrum of harmful plants controlled is not wide enough

Engineering Contradiction:

Improvespectrum of harmful plants controlledVSAvoidherbicidal activity

Core Design Contradiction:

Adaptability or versatilityVSReliability

Solution Approach 1:

The patent introduces substituted 2-aminoazines as a new class of herbicidal active substances that can control multiple types of harmful plants (broad-leaved weeds and weed grasses) with a single compound, expanding the spectrum of control while maintaining reliable herbicidal activity through the core chemical structure

Inventive Principle:

Principle #6Universality (Multi-functionality)

Solution Approach 2:

The patent modifies the chemical structure by substituting different groups at positions R1, R2, and R3 of the 2-aminoazine core, creating derivatives with varying herbicidal profiles that can target different harmful plant species while maintaining activity against common weeds

Inventive Principle:

Principle #35Parameter changes

2Reliability

If known herbicides are used for selective control, then herbicidal action is achieved, but selectivity in crops of useful plants is too low

Engineering Contradiction:

Improveselectivity in cropsVSAvoidharms to useful plants

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent introduces specific substituent patterns at different positions of the 2-aminoazine molecule (R1 at position 2, R2 at position 5, R3 at position 6) to create local chemical characteristics that differentiate the compound's interaction with crop plants versus harmful plants, enhancing selectivity through localized structural modifications

Inventive Principle:

Principle #3Local quality

3Reliability

If known herbicides are used, then herbicidal control is achieved, but toxicologically unfavourable profiles are observed

Engineering Contradiction:

Improveherbicidal controlVSAvoidtoxicological profile

Core Design Contradiction:

ReliabilityVSObject-generated harmful factors

Solution Approach 1:

The patent employs substituted 2-aminoazines with specific substituent groups (halogens, cyano, nitro, alkyl, alkoxy) that provide effective herbicidal control at appropriate application rates while maintaining favourable toxicological profiles, allowing for safe use and degradation in the environment

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

4Reliability

If known active ingredients are used, then herbicidal activity is achieved, but economic production is difficult due to precursor availability

Engineering Contradiction:

Improveherbicidal activityVSAvoidproduction economy

Core Design Contradiction:

ReliabilityVSEase of manufacture

Solution Approach 1:

The patent structures the 2-aminoazine molecule with distinct substitutable positions (R1, R2, R3) that can be independently modified using various commercially available precursors, allowing for flexible synthesis routes that can be optimized for economic production based on precursor availability

Inventive Principle:

Principle #1Segmentation

5Reliability

If known herbicides are used, then herbicidal action is achieved, but activity is too highly dependent on environmental conditions

Engineering Contradiction:

Improveherbicidal actionVSAvoiddependence on environmental conditions

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent creates substituted 2-aminoazines that combine a stable core heterocyclic structure with various substituent groups, providing compounds that maintain consistent herbicidal activity across different environmental conditions (weather and soil conditions) through the stabilizing effect of the core structure while the substituents provide environmental adaptability

Inventive Principle:

Principle #40Composite materials

Data Source

PatentUS20250311727A1Substituted 2-aminoazines and salts thereof, and use thereof as herbicidal active substances

Publication Date: 2025.10.09 BAYER AG

AI summary

Substituted 2-aminoazines and salts thereof, and use thereof as active herbicidal ingredientsSubstituted 2-aminoazines of the general formula (1) are described,and the use thereof as herbicides, in particular for controlling broad-leaved weeds and/or weed grasses in crops of useful plants and/or as plant growth regulators for influencing the growth of crops of useful plants.The present invention further relates to herbicidal and/or plant growth-regulating compositions comprising one or more compounds of the general formula (I).