Substituted Isoxazoline Compounds for Broad-Spectrum Pest Control
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Solution Overview
Problem
There is a need for highly effective and versatile agents that can combat a wide range of invertebrate pests, particularly difficult-to-control insects, with a broad activity spectrum.
Innovation Solution
The development of isoxazoline compounds of specific structural formulae, including their stereoisomers, salts, and N-oxides, which are synthesized through various chemical reactions such as amidation, Buchwald-Hartwig reaction, and Horner-Wadsworth-Emmons reaction, using starting materials and catalysts to achieve good pesticidal activity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If existing pesticidal compounds are used, then some pest control activity is achieved, but the activity spectrum is insufficient and difficult-to-control insects remain unaffected
Solution Approach 1:
The patent applies parameter changes by systematically modifying the chemical structure of isoxazoline compounds through varying substituents at different positions (R1-R6 groups). This structural parameter optimization enables the compounds to achieve both broad spectrum activity and high efficacy against difficult-to-control pests by tuning molecular properties to enhance pest control effectiveness.
2Reliability
If new pesticidal compounds with broad activity spectrum are developed, then efficacy against difficult-to-control pests improves, but the complexity of compound synthesis increases
Solution Approach 1:
The patent employs segmentation by dividing the complex molecule into distinct functional modules or building blocks that can be synthesized separately and then assembled. This modular approach to molecular construction simplifies the overall synthesis process while maintaining the complex structural features necessary for high pesticidal activity.
Solution Approach 2:
The patent applies universality by developing a core isoxazoline structure that serves multiple pesticidal functions and can target different pest types. This multi-functional core structure reduces synthesis complexity by using a single versatile platform that can be adapted to achieve broad-spectrum activity rather than requiring separate specialized compounds for each pest type.
Data Source
AI summary
The invention relates to isoxazoline compounds of formula (I) wherein the variables have the meanings as defined in the specification, to compositions comprising them, to active compound combinations comprising them, and to their use for protecting growing plants and animals from attack or infestation by invertebrate pests, furthermore, to seed comprising such compounds.