Sucralose-6-Ester Purification via Enzymatic Hydrolysis
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Solution Overview
Problem
The existing methods for purifying sucralose-6-ester are inefficient, leading to high energy consumption, low separation efficiency, and difficulty in treating subsequent waste solutions, resulting in low yield and economic value, with polychlorinated compounds not being utilized effectively.
Innovation Solution
A method involving the use of an oxidant and an alkaline hydrolysis agent to convert impurities like sucralose diester and tetrachlorosucrose-6-ester into sucralose-6-ester, involving steps such as oxidation, alkaline hydrolysis, pH adjustment, extraction, and crystallization to improve yield and purity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If conventional extraction by boiling many times is used to treat repeated mother solution, then impurities can be removed, but energy consumption is high and separation efficiency is low
Solution Approach 1:
The patent changes the chemical parameters of the repeated mother solution by adjusting pH to alkaline conditions (pH 8-10) and adding specific enzymes (esterase or lipase). This transforms the chemical state of impurities, enabling selective hydrolysis of polychlorinated compounds into sucralose-6-ester, thereby improving separation efficiency without requiring multiple boiling extractions.
Solution Approach 2:
The patent replaces the mechanical/thermal extraction process (boiling many times) with a biochemical approach using enzymes. The enzyme-catalyzed hydrolysis selectively converts impurities at mild conditions, substituting the energy-intensive mechanical extraction system with a more efficient biochemical system.
2Manufacturing precision
If multiple extraction and recrystallization steps are performed, then purity of sucralose-6-ester can be improved, but yield is reduced due to loss in mother solution
Solution Approach 1:
The patent converts the harmful impurities (polychlorinated compounds like sucralose diester) in the repeated mother solution into beneficial target product (sucralose-6-ester) through enzyme-catalyzed hydrolysis. This transforms waste material into valuable product, simultaneously improving purity and recovering yield that would otherwise be lost.
Solution Approach 2:
Instead of discarding the repeated mother solution containing impurities, the patent recovers valuable sucralose-6-ester from it by converting impurities into the target product through enzymatic hydrolysis, followed by extraction and crystallization, thereby recovering material that would have been wasted.
3Manufacturing precision
If repeated crystallization is performed to purify sucralose-6-ester, then purity increases, but processing time and complexity increase
Solution Approach 1:
The patent performs preliminary enzymatic treatment of the repeated mother solution before extraction and crystallization. By pre-converting impurities into sucralose-6-ester through enzyme hydrolysis, the subsequent extraction and crystallization steps become more efficient, reducing the number of repeated cycles needed and thereby reducing processing time.
Solution Approach 2:
The patent introduces enzymes (esterase or lipase) as intermediaries to facilitate the conversion of impurities. These enzymes act as mediators that selectively transform polychlorinated compounds into sucralose-6-ester under mild conditions, simplifying the overall purification process and reducing time compared to conventional repeated crystallization.
4Object-generated harmful factors
If conventional treatment of repeated mother solution is used, then polychlorinated compounds are removed as waste, but environmental pressure increases due to large amount of waste
Solution Approach 1:
The patent converts harmful polychlorinated compounds (sucralose diester, tetrachlorosucrose-6-ester) into beneficial target product (sucralose-6-ester) through enzyme-catalyzed hydrolysis. This transforms waste pollutants into valuable chemical product, eliminating environmental disposal issues and reducing environmental pressure.
Solution Approach 2:
Instead of discarding polychlorinated compounds as harmful waste, the patent recovers them by converting into sucralose-6-ester through enzymatic treatment, followed by extraction and crystallization. This recovery process eliminates waste disposal and reduces environmental pressure.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This method significantly improves the yield of sucralose-6-ester, reduces impurity content in wastewater, and is environmentally friendly, offering high economic value and practicality.
Implementation Method 1
adding an oxidant into a mother solution to be purified, carrying out oxidation reaction under a first preset condition
Implementation Method 2
adding an alkaline hydrolysis agent thereto, and carrying out alkaline hydrolysis reaction under a second preset condition
Implementation Method 3
extracting the first aqueous phase by using an extractant
Implementation Method 4
concentrating the mother solution to be crystallized
Implementation Method 5
crystallizing under a third preset condition to obtain a crude sucralose-6-ester product
Data Source
AI summary
The present application provides a method for purifying sucralose-6-ester. The method comprises: adding an oxidizing agent to a mother solution to be purified, carrying out an oxidation reaction under a first preset condition, then adding an alkaline hydrolysis agent thereto, and carrying out an alkaline hydrolysis reaction under a second preset condition to convert a target impurity into sucralose-6-ester so as to obtain an oxidized alkaline hydrolysis reaction solution; adjusting the pH value of the oxidized alkaline hydrolysis reaction solution to be neutral, keeping same for a period of time, then heating and filtering same to remove insoluble impurities, and then carrying out liquid separation to obtain a first aqueous phase and a first organic phase; extracting the first aqueous phase by using an extracting agent, and combining a second organic phase, which is obtained by means of the extraction, with the first organic phase to obtain a mother solution to be crystallized; and a step of crystallization, involving: concentrating the mother solution to be crystallized, and carrying out crystallization under a third preset condition to obtain a crude product of sucralose-6-ester and a first filtrate. By means of the present application, the yield of a target product is greatly improved while the impurity content is effectively removed.