Sucralose Extraction Efficiency via Concentration and Solvent
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Solution Overview
Problem
Current processes for producing sucralose often result in varying amounts of impurities, leading to yield loss and increased costs during purification, with a need for more efficient methods to achieve high-purity sucralose on a large scale.
Innovation Solution
A multi-step process involving the extraction of sucralose from aqueous feed streams using immiscible organic solvents, such as ethyl acetate, to selectively separate sucralose from impurities, with recycling of aqueous streams to enhance purification efficiency and minimize yield loss.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If conventional purification processes are used to remove impurities from sucralose, then impurity levels are reduced, but sucralose yield is lost and operational costs increase
Solution Approach 1:
The patent applies parameter changes by adjusting the concentration of the aqueous feed stream to optimize the partition coefficient during extraction. By controlling the concentration parameter, the process achieves high purity sucralose recovery while minimizing yield loss, as the extraction efficiency is maximized at specific concentration ranges
Solution Approach 2:
The patent uses an organic solvent as an intermediary substance to facilitate the separation of sucralose from impurities. The organic solvent acts as a mediator that selectively extracts sucralose from the aqueous phase, enabling high purity recovery without direct contact between sucralose and impurity removal mechanisms that would cause yield loss
2Manufacturing precision
If conventional purification processes are used to remove impurities from sucralose, then impurity levels are reduced, but operational costs increase
Solution Approach 1:
The patent optimizes operational costs by adjusting process parameters including feed stream concentration, solvent-to-feed ratio, and extraction stage conditions. These parameter changes enable high purity sucralose production with reduced operational costs through improved extraction efficiency and minimized material losses
Solution Approach 2:
The patent implements continuous extraction processes where the organic solvent continuously contacts the aqueous feed stream, maintaining optimal extraction conditions throughout the process. This continuous action improves purity while reducing operational costs compared to batch processes that require repeated setup and teardown
3Ease of operation
If extraction is performed with dilute aqueous feed streams, then the process is simpler to operate, but extraction efficiency is reduced
Solution Approach 1:
The patent changes the concentration parameter of the aqueous feed stream to optimize extraction efficiency. By operating at specific concentration ranges rather than dilute conditions, the process achieves higher extraction efficiency while maintaining operational simplicity through standardized feed preparation procedures
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The process effectively reduces impurity levels in the aqueous stream while maintaining high sucralose yield, achieving significant purity improvements with minimal operational costs, as demonstrated by increased extraction efficiency and purity levels with higher organic solvent ratios and concentrated feed streams.
Implementation Method 1
extracting an aqueous feed stream comprising sucralose with a first organic solvent and producing a first organic extract and a first aqueous extract, in which the organic solvent is immiscible with water, and a portion of the sucralose passes into the first organic extract
Data Source
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AI summary
A process for the purification of aqueous feed streams containing sucralose comprises: a) extracting an aqueous feed stream comprising sucralose with a first organic solvent and producing a first organic extract and a first aqueous extract, in which the organic solvent is immiscible with water, and a portion of the sucralose passes into the first organic extract; b) optionally extracting the first organic extract with an aqueous solvent to produce a second organic extract and a second aqueous extract, in which the sucralose preferentially passes into the second aqueous extract, and in which the second aqueous extract is recycled to step a); c) concentrating the first aqueous extract to form a concentrated aqueous feed stream; and d) extracting the concentrated aqueous feed stream with a second organic solvent and producing a third organic extract and a third aqueous extract, in which the second organic solvent is immiscible with water, and in which the sucralose preferentially passes into the third organic extract. A process for the purification of aqueous feed streams containing sucralose-6- esters comprises the steps of: a) providing an aqueous feed stream comprising a carbohydrate selected from the group consisting of sucralose 6-esters, and mixtures thereof with sucralose; b) concentrating the aqueous feed stream to form a concentrated aqueous feed stream; and c) extracting the concentrated aqueous feed stream with an organic solvent and producing an organic extract and an aqueous extract, in which the organic solvent is immiscible with water, and in which the carbohydrate preferentially passes into the organic extract.