Solid-Form Sucrosomial Formulations for Nutrient Bioavailability

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Solution Overview

Problem

Existing formulations of chromium, copper, and vitamins suffer from low gastrointestinal absorption and blood bioavailability, leading to variable efficacy and poor treatment outcomes for deficiencies and related metabolic disorders, with challenges in stability, tolerance, and cost-effectiveness.

Innovation Solution

Development of sucrosomial formulations comprising chromium, copper, or vitamins, which include a chromium salt or complex, phospholipids, sucresters, and optionally plant starch, to enhance gastrointestinal absorption and blood bioavailability, ensuring stability and broad subject tolerance.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional chromium formulations are administered orally, then chromium is delivered to the gastrointestinal tract, but gastrointestinal absorption and blood bioavailability are low (0.5%-2%), leading to variable efficacy

Engineering Contradiction:

Improvegastrointestinal absorption and blood bioavailabilityVSAvoidtreatment efficacy

Core Design Contradiction:

ReliabilityVSProductivity

Solution Approach 1:

The patent applies composite materials by formulating chromium within a complex structure comprising phospholipids, sucresters, and optionally plant starch. This composite formulation (sucrosomial Chromium®) enhances gastrointestinal absorption and blood bioavailability compared to conventional chromium salts alone, directly addressing the low absorption issue while improving treatment efficacy.

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The patent changes the physical and chemical parameters of chromium delivery by using specific phospholipid types, sucrester ratios, and formulation conditions. These parameter changes transform the absorption characteristics of chromium from poor (0.5%-2%) to significantly improved levels, resolving the contradiction between reliable delivery and effective treatment.

Inventive Principle:

Principle #35Parameter changes

2Reliability

If higher doses of chromium are administered to overcome low bioavailability, then more chromium reaches the bloodstream, but tolerance and cost-effectiveness deteriorate

Engineering Contradiction:

Improveblood bioavailabilityVSAvoidtolerance and cost-effectiveness

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The composite sucrosomial Chromium® formulation achieves high blood bioavailability without requiring high doses. The phospholipid-sucreste plant starch complex efficiently delivers chromium at lower concentrations, avoiding the tolerance issues and excessive costs associated with high-dose conventional chromium administration.

Inventive Principle:

Principle #40Composite materials

3Ease of manufacture

If conventional formulations are used, then manufacturing is simple, but stability and treatment outcomes are poor

Engineering Contradiction:

Improveformulation simplicityVSAvoidformulation stability

Core Design Contradiction:

Ease of manufactureVSStability of the object's composition

Solution Approach 1:

The patent develops a composite formulation system using phospholipids, sucresters, and plant starch that provides enhanced stability while remaining manufacturable. The specific combination of these components creates a stable complex that protects chromium during storage and digestion, improving treatment outcomes without excessive manufacturing complexity.

Inventive Principle:

Principle #40Composite materials

4Adaptability or versatility

If variable chromium absorption occurs between subjects, then individual responses differ significantly, but consistent treatment protocols become ineffective

Engineering Contradiction:

Improveindividual response variabilityVSAvoidtreatment consistency

Core Design Contradiction:

Adaptability or versatilityVSReliability

Solution Approach 1:

The sucrosomial Chromium® composite formulation provides consistent and reliable chromium delivery across different subjects. The phospholipid-sucreste plant starch complex creates a standardized delivery system that reduces inter-individual variability in absorption, enabling consistent treatment protocols to be effective across diverse patient populations.

Inventive Principle:

Principle #40Composite materials

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The sucrosomial formulations significantly increase gastrointestinal absorption and blood bioavailability, allowing for effective treatment of deficiencies and metabolic disorders at lower doses, with improved stability, tolerance, and cost-effectiveness.

Implementation Method 1

at least one phospholipid

Methodology Applied

Scientific EffectMicelle formation: Emulsion

Implementation Method 2

at least one phospholipid

Methodology Applied

Scientific EffectLiposome formation: Emulsion

Implementation Method 3

at least one first agent selected from a sucrester (alternatively called fatty acid carbohydrate ester)

Methodology Applied

Scientific EffectSurfactant action: Surfactant

Data Source

PatentUS20250275982A1Solid form formulation comprising chromium or copper or a vitamin, compositions and uses thereof

Publication Date: 2025.09.04 ALESCO SRL

AI summary

A solid form formulation comprising chromium (sucrosomial Chromium®) or copper (sucrosomial Copper®) or a vitamin (sucrosomial Vitamin®) and related composition, process for the preparation and method for treatment of a chromium deficiency and/or a change in the carbohydrate metabolism and/or a change in the muscle energy metabolism are described.