Sugar-Based Delivery System for Skin Penetration and Stability

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Solution Overview

Problem

Existing cosmetic delivery systems based on hydrophobized polysaccharides do not penetrate the skin effectively and can cause skin irritation, and there is a need for a stable and efficient method to encapsulate lipophilic cosmetic actives for enhanced skin penetration and stability.

Innovation Solution

A physically stable, positively charged water-based sugar delivery system that encapsulates lipophilic cosmetic actives, utilizing a sugar-based emulsifier, coemulsifiers, and positively charged molecules to form a skin-penetrating composition, which is stable at elevated temperatures and reduces skin irritation.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Stability of the object's composition

If hydrophobized polysaccharides are used as delivery systems, then film forming properties are improved, but skin penetration ability deteriorates

Engineering Contradiction:

Improvefilm forming propertiesVSAvoidskin penetration ability

Core Design Contradiction:

Stability of the object's compositionVSEase of operation

Solution Approach 1:

The delivery system is segmented into distinct functional components: hydrophobized polysaccharide particles for film formation and positively charged vesicles for skin penetration. This segmentation allows each component to optimize its specific function without compromising the other, resolving the contradiction between film forming properties and penetration ability

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The invention uses a composite delivery system combining hydrophobized polysaccharides with positively charged vesicles containing cosmetic actives. This composite structure integrates the film-forming capability of polysaccharides with the penetration-enhancing properties of charged vesicles, achieving both functions simultaneously

Inventive Principle:

Principle #40Composite materials

2Stability of the object's composition

If hydrophobized polysaccharides are used as delivery systems, then film forming properties are improved, but skin irritation increases

Engineering Contradiction:

Improvefilm forming propertiesVSAvoidskin irritation

Core Design Contradiction:

Stability of the object's compositionVSObject-affected harmful factors

Solution Approach 1:

Positively charged vesicles act as intermediaries between the hydrophobized polysaccharide film and the skin. These vesicles deliver cosmetic actives through the film to the skin, reducing direct contact between potentially irritating polysaccharides and skin while maintaining film-forming benefits

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The invention modifies the charge parameter of the delivery system by introducing positively charged vesicles. This parameter change allows the system to interact more gently with skin while maintaining film-forming properties, thereby reducing skin irritation

Inventive Principle:

Principle #35Parameter changes

3Ease of operation

If lipophilic cosmetic actives are encapsulated, then skin penetration is improved, but physical stability deteriorates

Engineering Contradiction:

Improveskin penetrationVSAvoidphysical stability

Core Design Contradiction:

Ease of operationVSStability of the object's composition

Solution Approach 1:

The invention uses vesicular structures with flexible membranes to encapsulate lipophilic cosmetic actives. These flexible shells protect the encapsulated actives while allowing controlled release and penetration through skin, maintaining both stability and penetration ability

Inventive Principle:

Principle #30Flexible shells and thin films

Solution Approach 2:

The delivery system employs a composite structure combining hydrophobized polysaccharides with vesicles containing lipophilic actives. This composite approach provides physical stability through the polysaccharide framework while enabling skin penetration through the vesicular carriers

Inventive Principle:

Principle #40Composite materials

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The sugar-based delivery system effectively penetrates the skin, enhances the stability of encapsulated actives, and reduces skin irritation, as confirmed by 5D Intravital tomography, maintaining stability and efficacy over time.

Implementation Method 1

a positively charged water based penetrating sugar based delivery system with the ability to encapsulate at least one or a combination of oil soluble/oil miscible/oil dispersible cosmetic actives

Methodology Applied

Scientific EffectElectrostatic interaction: Electrostatics

Implementation Method 2

penetrating the skin thereby delivering the cosmetic actives into the skin

Methodology Applied

Scientific EffectDiffusion: Diffusion

Implementation Method 3

consisting of a sugar based emulsifier coemulsifiers, positively charged molecules, minimum one oil, solvents

Methodology Applied

Scientific EffectMicelle formation: Emulsion

Data Source

PatentUS20230301896A1Composition for penetrating sugar based delivery system

Publication Date: 2023.09.28 EVONIK OPERATIONS GMBH

AI summary

A water based composition contains a sugar based delivery system, coemulsifiers, a positively charged molecule, oil, optional auxiliary materials, and optional lipophilic active ingredients. The composition is encapsulated to be used in personal care products including cosmetics. The composition is penetrating into the skin and is, depending on the active included, able to stabilize the substance and reduce its irritation potential.