Sugar Cane Polyphenol Extract for Glucose Control
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Solution Overview
Problem
Existing products fail to effectively manage insulin resistance and type 2 diabetes by not balancing postprandial glucose and insulin responses, leading to potential hypoglycemia and not considering the insulin response adequately, which is crucial for managing conditions like obesity and diabetes.
Innovation Solution
A sugar-cane derived extract enriched in polyphenols, obtained through hydrophobic chromatography or ion exclusion chromatography, is administered to lower postprandial glucose and insulin responses without causing hypoglycemia, thereby addressing the imbalance and providing a therapeutic benefit for insulin resistance and type 2 diabetes.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If existing products are used to lower blood glucose levels, then postprandial glucose response is reduced, but insulin response becomes unbalanced leading to hypoglycemia
Solution Approach 1:
The patent applies parameter changes by modifying the chemical composition parameters of the extract through controlled processing methods (hydrophobic chromatography, ion exclusion chromatography, ultrafiltration) to achieve optimal polyphenol concentration ranges (20-30g/100g for hydrophobic chromatography, 4-8g/100g for ion exclusion chromatography). These parameter adjustments enable the extract to lower postprandial glucose and insulin responses effectively without causing hypoglycemia, resolving the contradiction between glucose control accuracy and insulin response balance
Solution Approach 2:
The patent employs composite materials by creating a complex mixture of polyphenolic compounds from sugar cane molasses that includes multiple types of polyphenols (flavonoids, phenolic acids, stilbenes) working synergistically. This composite approach allows the extract to modulate both glucose and insulin responses simultaneously, achieving balanced blood glucose management without the hypoglycemic side effects associated with single-component products
2Reliability
If polyphenol concentration is increased to improve insulin sensitivity, then therapeutic effect is enhanced, but risk of hypoglycemia increases
Solution Approach 1:
The patent utilizes parameter changes by establishing specific polyphenol concentration ranges achieved through controlled chromatographic processes. The hydrophobic chromatography method produces extracts with 20-30g polyphenols/100g, while ion exclusion chromatography produces 4-8g polyphenols/100g. These controlled parameter changes optimize insulin sensitivity improvement while the presence of accompanying compounds (sugars, organic acids, minerals) buffers against hypoglycemia, resolving the contradiction between therapeutic effect and safety
Solution Approach 2:
The patent applies the intermediary principle by using sugars, organic acids, and minerals present in the molasses-derived extract as mediators that modulate the action of polyphenols. These intermediary substances prevent excessive insulin secretion and glucose uptake, thereby reducing hypoglycemia risk while maintaining the insulin sensitivity-enhancing effects of polyphenols. This creates a balanced therapeutic profile that improves insulin sensitivity without causing harmful hypoglycemic events
3Productivity
If waste products from sugar refining are utilized, then resource efficiency is improved, but product purity and consistency become difficult to control
Solution Approach 1:
The patent applies parameter changes by implementing controlled processing parameters including pH adjustment, temperature control, and flow rate optimization during hydrophobic and ion exclusion chromatography. These parameter controls enable consistent separation and concentration of polyphenols from molasses, achieving reproducible extract composition (20-30g or 4-8g polyphenols/100g depending on method) while maximizing resource utilization from sugar refining waste
Solution Approach 2:
The patent replaces traditional mechanical filtration methods with chromatographic separation techniques (hydrophobic chromatography using C18 columns and ion exclusion chromatography using sulfonic acid resin). This substitution enables precise control over extract composition and consistency by separating compounds based on their chemical properties rather than physical filtration, thereby achieving manufacturing precision while utilizing waste molasses efficiently
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The sugar-cane derived extract effectively reduces postprandial glucose and insulin responses, ensuring a safer therapeutic window that avoids hypoglycemia, thus providing a balanced management of glucose levels and insulin sensitivity for treating obesity and type 2 diabetes.
Implementation Method 1
comprising the retained compounds of molasses subjected to hydrophobic chromatography
Implementation Method 2
after passing the extract through a 30-35 kDa filter by ion exclusion chromatography
Implementation Method 3
after passing the extract through a 30-35 kDa filter by ion exclusion chromatography
Data Source
Figure 1
Figure 2
Figure 3A
AI summary
The invention relates to extracts produced from sugar cane processing stream products having desirable properties and health benefits. More particularly the invention relates to sugar cane derived extracts obtained from molasses, methods of producing the extracts, and uses of the extracts for management of insulin resistant conditions or subjects predisposed to such conditions, such as type 2 diabetes. The sugar cane derived extracts of the invention are enriched in polyphenols and the administration of the sugar cane derived extract regulates postprandial glucose response and insulin response and lowering those responses, to avoid the subject becoming hypoglycaemic.