Sulfated Polysaccharides Blocking SARS-CoV-2 S-Protein Binding
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Solution Overview
Problem
Current anti-novel coronavirus medications lack effective mechanisms to prevent the virus from binding to host cells or inhibiting its replication within the cells, posing a challenge in treating and preventing infections caused by the SARS-CoV-2 virus.
Innovation Solution
Utilizing sea cucumber polysaccharides, fucoidans, and carrageenans to target the S protein on the virus, preventing cell binding and replication by developing medications, food products, and protective articles that inhibit the SARS-CoV-2 virus from infecting body cells.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional medications are used to treat novel coronavirus, then treatment is provided, but they lack effective mechanisms to prevent virus binding to host cells or inhibiting replication
Solution Approach 1:
The patent uses sulfated polysaccharides as intermediary substances that bind to the S protein of the coronavirus, preventing it from attaching to ACE2 receptors on host cells. These polysaccharides act as mediators that interfere with the virus-host cell interaction without requiring complex molecular mechanisms, thereby improving medication effectiveness while maintaining simplicity.
Solution Approach 2:
The patent modifies the chemical structure of natural polysaccharides by sulfation to enhance their antiviral activity. This parameter change (adding sulfate groups) transforms ordinary polysaccharides into potent antiviral agents that can effectively inhibit coronavirus binding and replication, improving therapeutic effectiveness through chemical modification rather than complex mechanism design.
2Reliability
If sulfated polysaccharides are used to prevent virus binding and replication, then antiviral effectiveness is improved, but research and development time and resources are increased
Solution Approach 1:
The patent leverages naturally occurring polysaccharides from marine organisms (sea cucumber, brown algae, red algae) that possess inherent antiviral properties. By utilizing these self-service natural compounds and simply modifying them through sulfation, the R&D process avoids the need to design and synthesize complex antiviral molecules from scratch, thereby reducing development time while achieving effective antiviral results.
Solution Approach 2:
The patent converts the abundance and accessibility of natural polysaccharides, which were previously considered mere dietary components, into potent antiviral medications. By recognizing and utilizing the hidden antiviral potential in these natural substances, the research process becomes more efficient, transforming readily available materials into effective treatments without requiring extensive R&D resources.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Sea cucumber polysaccharides and fucoidans demonstrate significant inhibition of SARS-CoV-2 virus entry into cells, while carrageenans show efficacy in preventing infection, with both external applications and oral administration providing additional health benefits like enhancing immunity and improving intestinal flora.
Implementation Method 1
The sea cucumber polysaccharides can bind to an S protein on the surface of the SARS-CoV-2 virus to prevent the SARS-CoV-2 virus from invading body cells
Implementation Method 2
The fucoidans have a plurality of functions including removing Helicobacter pylori
Implementation Method 3
some studies have found that the carrageenans have a plurality of physiological activities, including anticoagulation, blood lipid lowering, immunomodulation
Data Source
AI summary
The disclosure provides application of sulfated polysaccharides in resisting novel coronavirus, belonging to the technical field of biomedicine. It is confirmed in the disclosure that by binding to an S protein on the surface of the SARS-CoV-2 virus, the sea cucumber polysaccharides, fucoidans or carrageenans can prevent cell membranes of body cells from adsorbing and internalizing the SARS-CoV-2 virus, thereby preventing the SARS-CoV-2 virus from infecting the body cells, which indicates that the sea cucumber polysaccharides, fucoidans or carrageenans have the effect of prevention and treatment of pneumonia caused by the novel coronavirus. These polysaccharides can be used to prepare protective articles having functions of prevention and treatment of novel coronavirus infection, for example: inhalations, hand lotions, oral liquids and respirators.